Brief Communication

Journal of Nanoparticle Research

, Volume 11, Issue 6, pp 1509-1512

Silicon nitride nanoparticles for surface-assisted laser desorption/ionization of small molecules

  • Mohammadreza ShariatgorjiAffiliated withDepartment of Analytical Chemistry, Stockholm University
  • , Nahid AminiAffiliated withDepartment of Analytical Chemistry, Stockholm University
  • , Leopold L. IlagAffiliated withDepartment of Analytical Chemistry, Stockholm University Email author 

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Abstract

Conventional matrix-assisted laser desorption/ionization mass spectrometry is limited to analyses of higher molecular weight compounds due to high background noise generated by the matrix in the lower mass region. Surface-assisted laser desorption/ionization (SALDI) mass spectrometry is an alternative solution to this problem. Nanoparticles, structured silicon surfaces and carbon allotropes are commonly used as SALDI surfaces. Here, for the first time, we demonstrate the application of silicon nitride nanoparticles as a suitable medium for laser desorption/ionization of small drug molecules.

Keywords

Silicon nitride nanoparticles Surface-assisted laser desorption/ionization mass spectrometry Small molecules