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Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs

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Abstract

A magnetic nanosystem that simultaneously implements the cyclodextrin–drug complexation power, bioadhesive property of gum arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin (HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting prospect for drug delivery.

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Acknowledgment

This work was supported by the Landmark Project of National Cheng Kung University, Taiwan. We are also grateful to the National Science Council (Contract No. NSC 95-2221-E006-406-MY2) of the Republic of China for the support of this research.

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Correspondence to Dong-Hwang Chen.

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Banerjee, S.S., Chen, DH. Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs. J Nanopart Res 11, 2071–2078 (2009). https://doi.org/10.1007/s11051-008-9572-z

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  • DOI: https://doi.org/10.1007/s11051-008-9572-z

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