Research Paper

Journal of Nanoparticle Research

, Volume 11, Issue 8, pp 2071-2078

Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs

  • Shashwat S. BanerjeeAffiliated withDepartment of Chemical Engineering, National Cheng Kung University
  • , Dong-Hwang ChenAffiliated withDepartment of Chemical Engineering, National Cheng Kung University Email author 

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Abstract

A magnetic nanosystem that simultaneously implements the cyclodextrin–drug complexation power, bioadhesive property of gum arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin (HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting prospect for drug delivery.

Keywords

Magnetic Nanosystem Hydroxypropyl-cyclodextrin Hydrophobic drug Delivery Ketoprofen Nanomedicine