Research Paper

Journal of Nanoparticle Research

, Volume 11, Issue 8, pp 1925-1936

First online:

Gold nanoparticles modified GC electrodes: electrochemical behaviour dependence of different neurotransmitters and molecules of biological interest on the particles size and shape

  • D. CascheraAffiliated withISMN-CNR Email author 
  • , F. FedericiAffiliated withISMN-CNR
  • , D. ZaneAffiliated withISMN-CNR
  • , F. FocantiAffiliated withISMN-CNR
  • , A. CurulliAffiliated withISMN-CNR
  • , G. PadelettiAffiliated withISMN-CNR

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Gold colloidal nanoparticles (AuNps), synthesized by gold chloride hydrate (HAuCl4) chemical reduction were used to realize a modified glassy carbon electrode (GCE). Different shapes and sizes were observed, varying the molar ratio of HAuCl4 and polyvinylpyrrolidone (PVP). The electrochemical behaviour of different neurotransmitters and molecules of biological interest (dopamine, caffeic acid, catechol, uric acid, epinephrine and serotonin) were investigated by cyclic voltammetry (CV) at the AuNps modified GCE and a dependence of the electrochemical response on the size and the shape of the particles was observed. The electrochemical responses were stable during time with a generic decreasing of the peak current after 10 days ranging from 5–10% for catechol, uric acid and serotonine to 10–15% for the other analytes. A study on the electrochemical interface of modified electrodes was also carried out by means of electrochemical impedance spectroscopy (EIS).


Gold nanoparticles AuNp modified electrode Neurotransmitters Colloids Nanobiotechnology