Journal of Nanoparticle Research

, Volume 11, Issue 4, pp 909–916

Preparation and characterization of smart polymer brush-modified magnetic nanoparticles for biomedicine application

Authors

    • School of ScienceXi’an Jiaotong University
    • The National Center for Nanoscience and Technology
  • Yang Zhou
    • School of ScienceXi’an Jiaotong University
    • The National Center for Nanoscience and Technology
  • Wen Guan
    • School of ScienceXi’an Jiaotong University
  • Bingjun Ding
    • School of ScienceXi’an Jiaotong University
Research Paper

DOI: 10.1007/s11051-008-9481-1

Cite this article as:
Wang, S., Zhou, Y., Guan, W. et al. J Nanopart Res (2009) 11: 909. doi:10.1007/s11051-008-9481-1

Abstract

This paper investigates synthesis and characterization of smart polymer brush-modified magnetic nanoparticles (SPB-MNPs). Magnetic nanoparticles (MNPs) modified with poly(poly(ethylene glycol) monomethacrylate (poly(PEGMA)) brush were first functioned with activated pyridyldithio. Then, MNPs functioned with pyridyldithio (MNPs-PEG-PDT) were conjugated with 4-diamino-6-mercaptopyrimidine (DMP) to form SPB-MNPs via stimuli-responsive disulfide linkage. Fourier transform infrared spectra (FTIR) was used to monitor the preparation process of MNPs-PEG-PDT. MNPs-PEG-PDT is very highly reactive toward DMP. The disulfide linkage of SPB-MNPs can be cleaved by reduced glutathione (GHS). The concentration of GHS plays an important role in controlling the cleaved efficiency. The optimum concentration of GHS to release DMP is in the millimolar range.

Keyword

Magnetic nanoparticlesDisulfide linkageLiableGlutathioneSmartSynthesis

Copyright information

© Springer Science+Business Media B.V. 2008