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Pathogenesis of Dermatophytosis

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Abstract

Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to characterize secreted dermatophytic proteases at the molecular level, only punctual insights have been afforded into other aspects of the pathogenesis of dermatophytosis, such as fungal adhesion, regulation of gene expression during the infection process, and immunomodulation by fungal factors. However, new genetic tools were recently developed, allowing a more rapid and high-throughput functional investigation of dermatophyte genes and the identification of new putative virulence factors. In addition, sophisticated in vitro infection models are now used and will open the way to a more comprehensive view of the interactions between these fungi and host epidermal cells, especially keratinocytes.

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Abbreviations

DTH:

Delayed-type hypersensitivity

IH:

Immediate hypersensitivity

Sub:

Subtilisin

Mep:

Metalloprotease

DppIV:

Dipeptidyl-peptidase IV

TRM:

Trichophyton rubrum mannans

RFE:

Reconstructed feline epidermis

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Acknowledgments

We thank Prof. M. Monod (Dermatology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) for careful reading over and advice.

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Authors and Affiliations

  1. Department of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster, 20, 4000, Liège, Belgium

    Sandy Vermout, Jérémy Tabart, Aline Baldo, Anne Mathy, Bertrand Losson & Bernard Mignon

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  1. Sandy Vermout
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  2. Jérémy Tabart
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  4. Anne Mathy
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Correspondence to Bernard Mignon.

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Vermout, S., Tabart, J., Baldo, A. et al. Pathogenesis of Dermatophytosis. Mycopathologia 166, 267–275 (2008). https://doi.org/10.1007/s11046-008-9104-5

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