Article

Mycopathologia

, Volume 166, Issue 5, pp 267-275

Pathogenesis of Dermatophytosis

  • Sandy VermoutAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège
  • , Jérémy TabartAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège
  • , Aline BaldoAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège
  • , Anne MathyAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège
  • , Bertrand LossonAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège
  • , Bernard MignonAffiliated withDepartment of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège Email author 

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Abstract

Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to characterize secreted dermatophytic proteases at the molecular level, only punctual insights have been afforded into other aspects of the pathogenesis of dermatophytosis, such as fungal adhesion, regulation of gene expression during the infection process, and immunomodulation by fungal factors. However, new genetic tools were recently developed, allowing a more rapid and high-throughput functional investigation of dermatophyte genes and the identification of new putative virulence factors. In addition, sophisticated in vitro infection models are now used and will open the way to a more comprehensive view of the interactions between these fungi and host epidermal cells, especially keratinocytes.

Keywords

Dermatophytes Pathogenesis Trichophyton Microsporum