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Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene

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Abstract

The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity. In this research rs1421085 and rs9939609 polymorphisms of FTO gene were genotyped in 190 obese patients with a BMI ≥30 kg/m2 (Body Mass Index) and 97 healthy controls with a BMI of 18.5–24.9. Genotyping of SNPs was performed by real-time polymerase chain reaction. Body composition was established with bioelectric impedance analysis. Waist-to-hip ratio was determined for all participants. There were no significant differences (P > 0.05) between obese cases and controls in terms of genotype frequencies of rs1421085 and rs9939609 polymorphisms in our study. Also there were no significant correlations between genotypes and obesity related (anthropometric-body composition) parameters (P > 0.05).

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Acknowledgments

The authors disclosed receipt of the financial support for the research, authorship, and/or publication of this article. This study was supported by the Afyon Kocatepe University Scientific Research Projects Commission with a projected numbered as 11.TIP.05.

Conflicts of interest

The authors have reported no conflicts of interest.

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Authors and Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Mustafa Solak, Mujgan Ozdemir Erdogan, Saliha Handan Yildiz & Evrim Suna Arıkan Terzi

  2. Department of Physiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Kagan Ucok

  3. Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Seref Yuksel

  4. Family Health Center No: 2, Afyonkarahisar, Turkey

    Ahmet Bestepe

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  1. Mustafa Solak
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Correspondence to Mujgan Ozdemir Erdogan.

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Solak, M., Ozdemir Erdogan, M., Yildiz, S.H. et al. Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene. Mol Biol Rep 41, 7381–7386 (2014). https://doi.org/10.1007/s11033-014-3627-2

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  • DOI: https://doi.org/10.1007/s11033-014-3627-2

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