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RETRACTED ARTICLE: Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study

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This article was retracted on 06 June 2016

Abstract

Fibroblast growth factors (FGFs) and their receptors (FGFRs) play important roles in vascular system. FGFR4 rs351855 (Gly388Arg) polymorphism has shown to be a risk factor for many diseases. The aim of this study was to investigate the association between FGFR4 polymorphisms and the susceptibility to coronary artery disease (CAD) in the Chinese population. We identified three polymorphisms in the FGFR4 gene, rs351855G/A (Gly388Arg), rs145302848C/G and rs147603016G/A, by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) in 658 CAD cases and 692 healthy controls. Results showed that frequencies of GA genotype, AA genotype and A allele in rs351855 (Gly388Arg) polymorphism were significantly lower in CAD patients than in controls [odds ratio (OR) = 0.79, 95 % confidence intervals (CI) 0.62–0.99, P = 0.042; OR = 0.58, 95 % CI 0.41–0.81, P = 0.002; and OR = 0.77, 95 % CI 0.66–0.90, P = 0.001, respectively]. The rs147603016GA genotype and A allele also showed lower numbers in CAD cases (OR = 0.58, 95 % CI 0.36–0.93, P = 0.025; and OR = 0.59, 95 % CI 0.40–0.95, P = 0.028). The rs145302848C/G polymorphism did not show any correlation with CAD. Haplotype analysis revealed that the prevalence of ACG haplotype (rs351855, rs145302848 and rs147603016) was significantly decreased in CAD patients (P = 0.002). Our data suggested that the FGFR4 rs351855G/A (Gly388Arg) and rs147603016G/A polymorphisms could act as protective factors against CAD in the Chinese population and indicated that a single gene polymorphism could have diverse functions in different diseases.

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Authors and Affiliations

  1. Department of Cardiology, Qilu Hospital, Shandong University, 107 Wenhua West Road, Jinan, 250012, Shandong, China

    Qing Zhu & Tongtao Liu

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  1. Qing Zhu
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  2. Tongtao Liu
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Correspondence to Tongtao Liu.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s11033-016-3985-z.

The Editor-in-Chief of Molecular Biology Reports retracts the above-mentioned article per the Committee on Publication Ethics guidelines on plagiarism. The article duplicates (copies) significant paragraphs from the following main source/sources: Lan Ma, Haifeng Zhang, Carrie Han, Danian Tong, Meiyan Zhang, Yi'an Yao, Yu Luo, and Xuebo Liu, Fibroblast Growth Factor Receptor 4 Polymorphisms and Susceptibility to Coronary Artery Disease, DNA and Cell Biology. June 2012, 31(6): 1064-1069. doi:10.1089/dna.2011.1552.

Chen H, Tong J, Zou T, Shi H, Liu J, Du X, Yang J, Ma C, Fibroblast growth factor receptor 4 polymorphisms are associated with coronary artery disease. Genet Test Mol Biomarkers, 16:952–956, 2012.

These two articles were submitted within a relatively short time from each other which constitutes duplicate submission. In addition, further investigation showed irregularities in the peer review process leading us to believe that the peer review process was compromised.

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Zhu, Q., Liu, T. RETRACTED ARTICLE: Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study. Mol Biol Rep 39, 8679–8685 (2012). https://doi.org/10.1007/s11033-012-1723-8

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  • DOI: https://doi.org/10.1007/s11033-012-1723-8

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