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TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis

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Abstract

Colorectal cancer constitutes a significant proportion of the global burden of cancer morbidity and mortality. A number of studies have been conducted to explore whether TP53 codon 72 polymorphism is associated with colorectal cancer susceptibility. However, controversial results were obtained. In order to derive a more precise estimation of the relationship, we systematically searched Medline, Google scholar, and Ovid database for studies reported before May 2010. A total of 3603 colorectal cancer cases and 5524 controls were included. TP53 codon 72 polymorphism was not associated with colorectal cancer risk in all genetic models (for dominant model: OR = 0.99, 95% CI: 0.86–1.15; for recessive model: OR = 1.00, 95% CI: 0.81–1.23; for Arg/Pro vs. Arg/Arg: OR = 1.00, 95% CI: 0.87–1.15; for Pro/Pro vs. Arg/Arg: OR = 0.97, 95% CI: 0.76–1.25). In the subgroup analyses by ethnic groups and sources of controls, no significant associations were found in all models. Taken together, this meta-analysis suggested that the biologically usefulness of TP53 codon 72 polymorphism as a selection marker in colorectal cancer susceptibility may be very limited.

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Authors and Affiliations

  1. Department of Center for Disease Control and Prevention of Shaanxi Province, 3 Jiandong Road, 710043, Xi’an, Shaanxi, People’s Republic of China

    Jing-Jun Wang, Yuan Zheng, Li Wang, Peng-Bo Yu, Jian-Hua Dong, Lei Zhang, Jing Xu, Wei Shi & Yu-Chun Ren

  2. Department of Center for Disease Control and Prevention of Fuyang, Fuyang, China

    Liang Sun

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  1. Jing-Jun Wang
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  2. Yuan Zheng
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Correspondence to Yuan Zheng.

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Wang, JJ., Zheng, Y., Sun, L. et al. TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis. Mol Biol Rep 38, 4847–4853 (2011). https://doi.org/10.1007/s11033-010-0619-8

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