Article

Molecular Biology Reports

, Volume 37, Issue 1, pp 81-85

Increased serum interleukin 17 in patients with systemic lupus erythematosus

  • Xue-Fei ZhaoAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
  • , Hai-Feng PanAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
  • , Hui YuanAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
  • , Wen-Hui ZhangAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
  • , Xiang-Pei LiAffiliated withDepartment of Rheumatology, Anhui Provincial Hospital
  • , Gui-Hong WangAffiliated withDepartment of Rheumatology, Anhui Provincial Hospital
  • , Guo-Cui WuAffiliated withDepartment of Pharmacology, Anhui Medical University
  • , Hong SuAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
  • , Fa-Ming PanAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
    • , Wen-Xian LiAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
    • , Lian-Hong LiAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
    • , Guo-Ping ChenAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
    • , Dong-Qing YeAffiliated withDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University Email author 

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Abstract

Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity and defense against some bacteria, it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In the present study, we aimed to investigate the serum IL-17 level in patients with SLE and it’s associations with disease manifestations and activity. Fifty-seven patients with SLE and 30 healthy volunteers were recruited. Serum IL-17 levels were examined by enzyme linked immunosorbent assay (ELISA). Statistic analyzes were performed by SPSS 10.01. Results show that serum IL-17 levels were significantly elevated in SLE patients as compared with normal controls. Nevertheless, no associations of serum IL-17 level with clinical and laboratory parameters were found; no significant difference regarding serum IL-17 level between SLE patients with nephritis and those without nephritis was found; no significant difference was found between Less active SLE and More active SLE; Correlation analysis between serum IL-17 levels and SLEDAI showed no association. Taken together, our results indicate increased serum IL-17 levels in SLE patients, suggesting that this cytokine may trigger the inflammatory process in SLE. However, no associations of serum IL-17 level with disease manifestations were found. Therefore, further studies are required to confirm this preliminary data.

Keywords

Interleukin 17 Systemic lupus erythematosus