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An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions

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Abstract

A concise, efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives via a three-component reaction of 4-oxo-4H-chromene-3-carbaldehydes, malononitrile or cyanoacetates, and aromatic amines under catalyst-free conditions in an environmentally friendly medium (ethanol–water, 3:1 v/v) is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.

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Acknowledgements

We are grateful for the Major Basic Research Project of the Natural Science Foundation of Jiangsu Higher Education Institutions (15KJA150006), the financial support from the Natural Science Foundation of Jiangsu Province (BK20131160) and a Project Funded by the Priority Academic Project Development of Jiangsu Higher Education Institutions.

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  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People’s Republic of China

    Yong-Xiang Zheng, Zhan Xun, Juan-Juan Zhang, Zhi-Bin Huang & Da-Qing Shi

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  2. Zhan Xun
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  3. Juan-Juan Zhang
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Correspondence to Da-Qing Shi.

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Zheng, YX., Xun, Z., Zhang, JJ. et al. An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions. Mol Divers 21, 293–304 (2017). https://doi.org/10.1007/s11030-016-9723-6

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