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Multicomponent synthesis of diverse pyrano-fused benzophenazines using bifunctional thiourea-based organocatalyst in aqueous medium

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Abstract

A series of pyrano-fused benzophenazines were synthesized using a bifunctional thiourea-based organocatalyst from the one-pot four-component reaction of 2-hydroxy-1,4-naphthoquinone, benzene-1,2-diamines, malononitrile or its derivatives and isatins or aromatic aldehydes in aqueous medium. Metal-free reaction condition, water as solvent, high bond forming efficiency (five new bonds formed in one step), good yields and easy purification process are the notable features of this methodology.

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Acknowledgments

We are grateful to NIT Patna and the Department of Science and Technology, India for the financial support with Sanction No. SR/FT/CS-008/2010. The authors are grateful to IIT Patna and SAIF-Panjab University for providing the analytical facilities for characterization of products.

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  1. Department of Chemistry, National Institute of Technology Patna, Ashok Rajpath, Patna, 800005, India

    Ruchi Bharti & Tasneem Parvin

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  1. Ruchi Bharti
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Correspondence to Tasneem Parvin.

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Bharti, R., Parvin, T. Multicomponent synthesis of diverse pyrano-fused benzophenazines using bifunctional thiourea-based organocatalyst in aqueous medium. Mol Divers 20, 867–876 (2016). https://doi.org/10.1007/s11030-016-9681-z

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