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Calixdrugs: calixarene-based clusters of established therapeutic drug agents

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Abstract

Calixdrugs are calix[4]arene-based clusters (chaliced shapes) of established therapeutic drugs (e.g., penicillin, cephalosporin, tyrosol, and carboplatin) that are innovatively named calixpenam, calixcephem, calixtyrosol, and calixplatin, respectively. Going over the structures of cluster compounds, the calixarene scaffold lies at the heart of the structure (chaliced shape of drug), and it is an integral part of the cluster. In fact, the monomer drugs contribute as 1/4 of the corresponding cluster. In addition, probably because of the multivalency, spatial preorganization, and synergistic effect of four impacted drug units in the structures of calixdrugs, they are more effective in interactions with the target sites over their corresponding monomers.

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Acknowledgments

The author gratefully acknowledges the Urmia University of Medical Science for providing fellowships for the present work.

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  1. Health Technology Incubator Center, Urmia University of Medical Science, Urmia, Iran

    Fazel Nasuhi Pur

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  1. Fazel Nasuhi Pur
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Correspondence to Fazel Nasuhi Pur.

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In memory of my dear mother.

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Nasuhi Pur, F. Calixdrugs: calixarene-based clusters of established therapeutic drug agents. Mol Divers 20, 781–787 (2016). https://doi.org/10.1007/s11030-016-9667-x

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