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Psoralen derivatives as inhibitors of NF-\(\upkappa \hbox {B/DNA}\) interaction: the critical role of the furan ring

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Abstract

Simplified analogues of previously reported NF-\(\upkappa \hbox {B/DNA}\) interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-\(\upkappa \hbox {B}\).

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Acknowledgments

The project was supported by Telethon (GGP10124), CIB (Consorzio Interuniversitario di Biotecnologie) and FFC (Italian Cystic Fibrosis Research Foundation, contract FFC#2/2010).

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Authors and Affiliations

  1. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131, Padova, Italy

    Giovanni Marzaro, Paolo Manzini & Adriana Chilin

  2. Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121, Ferrara, Italy

    Ilaria Lampronti, Monica Borgatti & Roberto Gambari

  3. Biotechnology Center, University of Ferrara, Via Fossato di Mortara 64, 44121, Ferrara, Italy

    Roberto Gambari

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  1. Giovanni Marzaro
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  2. Ilaria Lampronti
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  3. Monica Borgatti
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  4. Paolo Manzini
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  5. Roberto Gambari
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  6. Adriana Chilin
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Correspondence to Adriana Chilin.

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Marzaro, G., Lampronti, I., Borgatti, M. et al. Psoralen derivatives as inhibitors of NF-\(\upkappa \hbox {B/DNA}\) interaction: the critical role of the furan ring. Mol Divers 19, 551–561 (2015). https://doi.org/10.1007/s11030-015-9586-2

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