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An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-\(b\)]indolone derivatives catalyzed by L-proline

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Abstract

An efficient and diastereoselective synthetic procedure for highly functionalized tetrahydroacenaphtho[1,2-\(b\)]indolone derivatives was successfully developed by the three-component reaction of acenaphthequinone, enaminones, and barbituric acid in the presence of a catalytic amount of L-proline. This method has the advantages of convenient operation, excellent yields, mild reaction conditions, and environmental friendliness.

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Acknowledgments

This work was financially supported by the Natural Science Foundation of Jiangsu Province (No. BK20131160), A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 11KJB150014).

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Authors and Affiliations

  1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People’s Republic of China

    Juan-Juan Zhang, Xian Feng, Xue-Cheng Liu, Zhi-Bin Huang & Da-Qing Shi

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  1. Juan-Juan Zhang
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  2. Xian Feng
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  3. Xue-Cheng Liu
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  4. Zhi-Bin Huang
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  5. Da-Qing Shi
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Correspondence to Da-Qing Shi.

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Zhang, JJ., Feng, X., Liu, XC. et al. An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-\(b\)]indolone derivatives catalyzed by L-proline. Mol Divers 18, 727–736 (2014). https://doi.org/10.1007/s11030-014-9544-4

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  • DOI: https://doi.org/10.1007/s11030-014-9544-4

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