JEDA: Joint entropy diversity analysis. An information-theoretic method for choosing diverse and representative subsets from combinatorial libraries
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The joint entropy-based diversity analysis (JEDA) program is a new method of selecting representative subsets of compounds from combinatorial libraries. Similar to other cell-based diversity analyses, a set of chemical descriptors is used to partition the chemical space of a library of compounds; however, unlike other metrics for choosing a compound from each partition, a Shannon-entropy based scoring function implemented in a probabilistic search algorithm determines a representative subset of compounds. This approach enables the selection of compounds that are not only diverse but that also represent the densities of chemical space occupied by the original chemical library. Additionally, JEDA permits the user to define the size of the subset that the chemist wishes to create so that restrictions on time and chemical reagents can be considered. Subsets created from a chemical library by JEDA are compared to subsets obtained using other partition-based diversity analyses, namely principal components analysis and median partitioning, on a combinatorial library derived from the Comprehensive Medical Chemistry Dataset.
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Volume 10, Issue 3 , pp 333-339
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- chemical diversity
- Shannon entropy
- representative subset selection
- Industry Sectors
- Author Affiliations
- 1. Graduate Program in Bioinformatics and Systems Biology, Boston, MA, 02215, U.S.A
- 2. Center for Chemical Methodology and Library Development, Boston, MA, 02215, U.S.A
- 3. Department of Chemistry, Boston University, Boston, MA, 02215, U.S.A