Skip to main content
Log in

Causal criteria and the problem of complex causation

  • Scientific Contribution
  • Published:
Medicine, Health Care and Philosophy Aims and scope Submit manuscript

Abstract

Nancy Cartwright begins her recent book, Hunting Causes and Using Them, by noting that while a few years ago real causal claims were in dispute, nowadays “causality is back, and with a vengeance.” In the case of the social sciences, Keith Morrison writes that “Social science asks ‘why?’. Detecting causality or its corollary—prediction—is the jewel in the crown of social science research.” With respect to the health sciences, Judea Pearl writes that the “research questions that motivate most studies in the health sciences are causal in nature.” However, not all data used by people interested in making causal claims come from experiments that use random assignment to control and treatment groups. Indeed, much research in the social and health science depends on non-experimental, observational data. Thus, one of the most important problems in the social and health sciences concerns making warranted causal claims using non-experimental, observational data; viz., “Can observational data be used to make etiological inferences leading to warranted causal claims?” This paper examines one method of warranting causal claims that is especially widespread in epidemiology and the health sciences generally—the use of causal criteria. It is argued that cases of complex causation generally, and redundant causation—both causal overdetermination and causal preemption—specifically, undermine the use of such criteria to warrant causal claims.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Notes

  1. Russell’s exact claim was that the word ‘cause’ should be expunged from the “philosophical vocabulary” since, in his view, physics had already expunged it from their vocabulary. However, regardless of whether Russell’s assessment of physics in 1912 was correct, as noted by Wesley Salmon (1998, p. 4), nowadays, causal concepts are ubiquitous in every branch of theoretical science, in the practical disciplines and in everyday life.

  2. Christopher Hitchcock (2003, p. 4) makes the same point, but uses cancer, smoking and stained teeth as his example, writing that “[L]ung cancer is correlated with both smoking and with stained teeth, but if we wish to avoid lung cancer, it will pay to quit smoking but not to whiten our teeth.”

  3. Developed for use in econometrics by the economist Clive Granger and named after him, “Granger causation” is a non-deterministic statistical account of causality that makes use of time-series data. (See Granger 1980; Holland 1986, pp. 957–958).

  4. Quoted in (Randall Jr. 1940, p. 220).

References

  • Bird, Alexander. 1998. The philosophy of science. Montreal: McGill-Queen’s University Press.

    Google Scholar 

  • Bunzl, Martin. 1979. Causal overdetermination. The Journal of Philosophy 76 (3): 134–150.

    Article  Google Scholar 

  • Carnap, Rudolf. 1995. An introduction to the philosophy of science. New York, NY: Dover Publications, Inc.

    Google Scholar 

  • Cartwright, Nancy. 1983. How the laws of physics lie. Oxford: Clarendon Press.

    Book  Google Scholar 

  • Cartwright, Nancy. 2002. Nature’s capacities and their measurement. Oxford: Clarendon Press.

    Google Scholar 

  • Cartwright, Nancy. 2007a. Counterfactuals in economics: A commentary. In Causation and explanation, ed. Joseph Keim Campbell, Michael O’Rourke, and Harry Silverstein, 191–216. Cambridge, MA: Bradford Books/MIT Press.

    Google Scholar 

  • Cartwright, Nancy. 2007b. Hunting causes and using them. Cambridge: Cambridge University Press.

    Google Scholar 

  • Chalmers, A.F. 1999. What is this thing called science?, 3rd ed. Indianapolis, IN: Hackett Publishing Co.

    Google Scholar 

  • Cobb, George W., and David S. Moore. 1997. Mathematics, statistics, and teaching. The American Mathematical Monthly 104 (9): 801–823.

    Article  Google Scholar 

  • DeMets, David L. 2002. Clinical trials in the new millennium. Statistics in Medicine 21 (19): 2779–2787.

    Article  PubMed  Google Scholar 

  • Eells, Ellery. 2001. Probabilistic causality. Cambridge: Cambridge University Press.

    Google Scholar 

  • Eells, Ellery, and Elliott Sober. 1983. Probabilistic causality and the question of transitivity. Philosophy of Science 50 (1): 35–57.

    Article  Google Scholar 

  • Egilman, David, Joyce Kim, and Molly Biklen. 2003. Proving causation: The use and abuse of medical and scientific evidence Inside the courtroom—an epidemiologist’s critique of the judicial interpretation of the Daubert ruling. Food and Drug Law Journal 58: 223–250.

    PubMed  Google Scholar 

  • Ehring, Douglas. 1997. Causation and persistence: A theory of causation. New York, NY: Oxford University Press.

    Google Scholar 

  • Environmental Protection Agency. 2005. Guidelines for carcinogen risk assessment—EPA/630/P-03/001f. Washington, DC: Risk Assessment Forum, U.S. Environmental Protection Agency.

    Google Scholar 

  • Field, Hartry. 2005. Causation in a physical world. In The Oxford handbook of metaphysics, ed. Michael J. Loux and Dean W. Zimmerman, 435–460. Oxford: Oxford University Press.

    Google Scholar 

  • Fletcher, Robert H., and Suzanne W. Fletcher. 2005. Clinical epidemiology: The essentials, 4th ed. Philadelphia, PA: Lippincott, Williams and Wilkins.

    Google Scholar 

  • Franco, Eduardo L., Pelayo Correa, Regina M. Santella, Xifeng Wu, Steven N. Goodman, and Gloria M. Petersen. 2004. Role and limitations of epidemiology in establishing a causal association. Seminars in Cancer Biology 14 (6): 413–426.

    Article  PubMed  Google Scholar 

  • Freedman, David A. 1999. From association to causation: Some remarks on the history of statistics. Statistical Science 14 (3): 243–258.

    Article  Google Scholar 

  • Gehlert, Sarah, Dana Sohmer, Tina Sacks, Charles Mininger, Martha McClintock, and Olufunmilayo Olopade. 2008. Targeting health disparities: A model linking upstream determinants to downstream interventions. Health Affairs 27 (2): 339–349.

    Article  PubMed  Google Scholar 

  • Goldthorpe, John H. 2001. Causation, statistics, and sociology. European Sociological Review 17 (1): 1–20.

    Article  Google Scholar 

  • Goodman, Karen J., and Carl V. Phillips. 2004. Hill criteria of causation. Online at http://www.cphps.org/papers/goodman-phillips_abhill-encybehavstat_mar04.pdf.

  • Granger, C.W.J. 1980. Testing for causality: A personal viewpoint. Journal of Economic Dynamics and Control 2: 329–352.

    Article  Google Scholar 

  • Greenland, Sander. 1990. Randomization, statistics, and causal inference. Epidemiology 1 (6): 421–429.

    Article  PubMed  CAS  Google Scholar 

  • Greenland, Sander. 2004. An overview of methods for causal inference from observational studies. In Applied Bayesian modeling and causal inference from incomplete-data perspectives, ed. Andrew Gelman and Xiao-Li Meng, 3–13. West Sussex: John Wiley and Sons.

    Google Scholar 

  • Hall, Ned. 2004. Two concepts of causation. In Causation and counterfactuals, ed. John Collins, Ned Hall, and L.A. Paul, 225–276. Cambridge, MA: Bradford Books/MIT Press.

    Google Scholar 

  • Hatch, Maureen C., and Zena A. Stein. 1986. Agent orange and risks to reproduction: The limits of epidemiology. Teratogenesis, Carcinogenesis, and Mutagenesis 6 (3): 185–202.

    Article  PubMed  CAS  Google Scholar 

  • Hausman, Daniel M. 1998. Causal asymmetries. Cambridge: Cambridge University Press.

    Google Scholar 

  • Hausman, Daniel M. 2005. Causal relata: Tokens, types, or variables? Erkenntnis 63: 33–54.

    Article  Google Scholar 

  • Hempel, Carl G. 1965. Confirmation, induction, and rational belief. In Aspects of scientific explanation and other essays in the philosophy of science, 3–46. New York, NY: The Free Press.

  • Hennekens, Charles H., and Julie E. Buring. 1987. Epidemiology in medicine. Philadelphia, PA: Lippincott Williams and Wilkins.

    Google Scholar 

  • Hernán, M.A. 2004. A definition of causal effect for epidemiological research. Journal of Epidemiology and Community Health 58: 265–271.

    Article  PubMed  Google Scholar 

  • Hill, Austin Bradford. 1965. The environment and disease: Association or causation? Proceedings of the Royal Society of Medicine 58: 295–300.

    PubMed  CAS  Google Scholar 

  • Hitchcock, Christopher. 1995. The mishap at Reichenbach fall: Singular vs. general causation. Philosophical Studies 78: 257–291.

    Google Scholar 

  • Hitchcock, Christopher. 2003. Of humean bondage. The British Journal for the Philosophy of Science 54: 1–25.

    Article  Google Scholar 

  • Hitchcock, Christopher. 2007. Prevention, preemption, and the principle of sufficient reason. The Philosophical Review 116 (4): 495–532.

    Article  Google Scholar 

  • Holland, Paul W. 1986. Statistics and causal inference. Journal of the American Statistical Association 81 (396): 945–960.

    Article  Google Scholar 

  • Holt, R.I.G., and R.C. Peveler. 2006. Antipsychotic drugs and diabetes—an application of the Austin Bradford Hill criteria. Diabetologia 49: 1467–1476.

    Article  PubMed  CAS  Google Scholar 

  • Hoover, Kevin D. 2001. Causality in macroeconomics. Cambridge: Cambridge University Press.

    Google Scholar 

  • Humphreys, Paul. 1989. The chances of explanation: Causal explanation in the social, medical, and physical sciences. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Jager, K.J., V.S. Stel, C. Wanner, C. Zoccali, and F.W. Dekker. 2007. The valuable contribution of observational studies to nephrology. Kidney International 72: 671–675.

    Article  PubMed  CAS  Google Scholar 

  • James, Robert C. 1994. Role of toxicology in toxic tort litigation: Establishing causation. Defense Counsel Journal 61: 28–39.

    Google Scholar 

  • Karhausen, L.R. 2000. Causation: The elusive grail of epidemiology. Medicine, Health Care and Philosophy 3: 59–67.

    Article  CAS  Google Scholar 

  • Kaufman, J.S., and C. Poole. 2000. Looking back on ‘causal thinking in the health sciences’. Annual Review of Public Health 21: 101–119.

    Article  PubMed  CAS  Google Scholar 

  • Kever, Ashley T. 2002. The plaintiff’s challenges to proving causation in today’s toxic tort landscape. State Bar of Texas Environmental Law Journal 33: 19–43.

    Google Scholar 

  • Kundi, Michael. 2006. Causality and the interpretation of epidemiologic evidence. Environmental Health Perspectives 114 (7): 969–974.

    Article  PubMed  Google Scholar 

  • Labarthe, Darwin R., and Reuel A. Stallones. 1988. Epidemiologic inference. In Causal inference, ed. Kenneth J. Rothman, 119–129. Chestnut Hill, MA: Epidemiology Resources, Inc.

    Google Scholar 

  • Lemen, Richard A. 2004. Chrysotile asbestos as a cause of mesothelioma: Application of the Hill Causation Model. International Journal of Occupational and Environmental Health 10 (2): 233–239.

    PubMed  Google Scholar 

  • Lewis, David. 1986. Philosophical papers, volume II. New York, NY: Oxford University Press.

    Google Scholar 

  • Loeb, Louis E. 1974. Causal theories and causal overdetermination. The Journal of Philosophy 71 (15): 525–544.

    Article  Google Scholar 

  • Lucas, Robyn M., and Anthony J. McMichael. 2005. Association or causation: Evaluating links between ‘environment and disease’. Bulletin of the World Health Organization 83 (10): 792–795.

    PubMed  Google Scholar 

  • Mackie, J.L. 1974. The cement of the universe: A study of causation. Oxford: Clarendon Press.

    Google Scholar 

  • McDermott, Michael. 1995. Redundant causation. The British Journal for the Philosophy of Science 46 (4): 523–544.

    Article  Google Scholar 

  • Mengersen, K., S.A. Moynihan, and R.L. Tweedie. 2007. Causality and association: The statistical and legal approaches. Statistical Science 22 (2): 227–254.

    Article  Google Scholar 

  • Morabia, Alfredo. 2004. Epidemiology: An epistemological perspective. In A history of epidemiologic methods and concepts, ed. Alfredo Morabia, 3–124. Berlin: Birkhäuser Verlag.

    Google Scholar 

  • Morrison, Keith. 2008. Editorial. Evaluation and Research in Education 21 (1): 1–3.

    Article  Google Scholar 

  • Muscat, Joshua E., and Micahel S. Huncharek. 1989. Causation and disease: Biomedical science in toxic tort litigation. Journal of Occupational Medicine 31 (12): 997–1002.

    Article  PubMed  CAS  Google Scholar 

  • Naschitz, Jochanan E., Julia Kovaleva, Naomi Shaviv, Gad Rennert, and Daniel Yeshurun. 2003. Vascular disorders preceding diagnosis of cancer: Distinguishing the causal relationship based on Bradford-Hill guidelines. Angiology 54 (1): 11–17.

    PubMed  Google Scholar 

  • Parascandola, M., and D.L. Weed. 2001. Causation in epidemiology. Journal of Epidemiology and Community Health 55: 905–912.

    Article  PubMed  CAS  Google Scholar 

  • Pearl, Judea. 2001. Causal inference in the health sciences: A conceptual introduction. Health Services and Outcomes Research Methodology 2: 189–220.

    Article  Google Scholar 

  • Perrio, Michael, Simon Voss, and Saad A.W. Shakir. 2007. Application of the Bradford Hill criteria to assess the causality of cisapride-induced arrhythmia: A model for assessing causal association in pharmacovigilance. Drug Safety 30 (4): 333–346.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, Carl V., and Karen J. Goodman. 2004. The missed lessons of Sir Austin Bradford Hill. Epidemiologic Perspectives and Innovations 1 (3). Online at http://www.epi-perspectives.com/content/1/1/3.

  • Randall, John Herman Jr. 1940. The making of the modern mind—revised edition. Boston, MA: Houghton Mifflin Company.

    Google Scholar 

  • Reiter, Jerome. 2000. Using statistics to determine causal relationships. The American Mathematical Monthly 107 (1): 24–32.

    Article  Google Scholar 

  • Rickles, Dean. 2008. Causality in complex interventions. Medicine, Health Care and Philosophy. doi: 10.1007/s11019-008-9140-4.

  • Rizzi, Dominick A., and Stig Andur Pedersen. 1992. Causality in medicine: Towards a theory and terminology. Theoretical Medicine 13: 233–254.

    Article  PubMed  CAS  Google Scholar 

  • Rosenbaum, Paul R. 1989. Safety in caution. Journal of Educational Statistics 14 (2): 169–173.

    Article  Google Scholar 

  • Rothman, Kenneth J. 1976. Causes. American Journal of Epidemiology 104 (6): 587–592.

    PubMed  CAS  Google Scholar 

  • Rothman, Kenneth J. 2002. Epidemiology: An introduction. Oxford: Oxford University Press.

    Google Scholar 

  • Rothman, Kenneth J., and Sander Greenland. 2005. Causation and causal inference in epidemiology. American Journal of Public Health 95 (S1): S144–S150.

    Article  PubMed  Google Scholar 

  • Rothman, Kenneth J., Sander Greenland, Charles Poole, and Timothy L. Lash. 2008. Causation and causal inference. In Modern epidemiology, 3rd edition, ed. Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash, 5–31. Philadelphia, PA: Lippincott, Williams and Wilkins.

    Google Scholar 

  • Russell, Bertrand. 1949. On the notion of cause, in mysticism and logic and other essays, 180–208. London: George Allen and Unwin, Ltd.

  • Russo, Frederica, and Jon Williamson. 2007. Interpreting causality in the health sciences. International Studies in the Philosophy of Science 21 (2): 157–170.

    Article  Google Scholar 

  • Salmon, Wesley C. 1998. Causality and explanation. New York, NY: Oxford University Press.

    Book  Google Scholar 

  • Schlesselman, James J., Bruce V. Stadel, Pamela Murray, Phyllis A. Wingo, and George L. Rubin. 1987. Consistency and plausibility in epidemiologic analysis: Application to breast cancer in relation to use of oral contraceptives. Journal of Chronic Diseases 40 (11): 1033–1039.

    Article  PubMed  CAS  Google Scholar 

  • Shadish, William R., Thomas D. Cook, and Donald T. Campbell. 2002. Experimental and quasi-experimental designs for generalized causal inference. Boston, MA: Houghton Mifflin Company.

    Google Scholar 

  • Shaffer, Terry L., and Douglas H. Johnson. 2008. Ways of learning: Observational studies versus experiments. Journal of Wildlife Management 72 (1): 4–13.

    Article  Google Scholar 

  • Shakir, S.A.W. 2004. Causality and correlation in pharmacovigilance. In Stephens’ detection of new adverse drug reactions, 5th ed, ed. John Talbot, and Patrick Walker, 329–343. West Sussex: John Wiley and Sons Ltd.

    Google Scholar 

  • Shakir, S.A.W., and Deborah Layton. 2002. Causal association in pharmacovigilance and pharmacoepidemiology: Thoughts on the application of the Austin Bradford-Hill criteria. Drug Safety 25 (6): 467–471.

    Article  PubMed  Google Scholar 

  • Smith, Herbert L. 1990. Specification problems in experimental and nonexperimental social research. Sociological Methodology 20: 59–91.

    Article  Google Scholar 

  • Sober, Elliott. 1984. The nature of selection: Evolutionary theory in philosophical focus. Cambridge, MA: Bradford Books/MIT Press.

    Google Scholar 

  • Suppes, Patrick. 1982. Arguments for randomizing. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 2: 464–475.

    Google Scholar 

  • Suppes, Patrick. 1985. Probabilistic metaphysics. Oxford: Basil Blackwell.

    Google Scholar 

  • Swaen, Gerard, and van Ludovic Amelsvoort. 2008. A weight of evidence approach to causal inference. Journal of Clinical Epidemiology. doi: 10.1016/j.jclinepi.2008.06.013.

  • Thompson, Melissa Moore. 1992–1993. Causal inference in epidemiology: Implications for toxic tort litigation. North Carolina Law Review 71: 247–291.

    Google Scholar 

  • United States Department of Health, Education and Welfare. 1964. Smoking and health: Report of the Advisory Committee to the Surgeon General of the Public Health Service. Washington, DC: United States Public Health Service.

    Google Scholar 

  • United States Department of Health and Human Services. 1982. The health consequences of smoking—cancer: A Report of the Surgeon General. Washington, DC: United States Public Health Service.

    Google Scholar 

  • Vandenbroucke, Jan P. 2004. When are observational studies as credible as randomised trials? Lancet 363: 1728–1731.

    Article  PubMed  Google Scholar 

  • Vineis, Paolo. 1991. Causality assessment in epidemiology. Theoretical Medicine 12: 171–181.

    Article  PubMed  CAS  Google Scholar 

  • Von Elm, Erik, Douglas G. Altman, Matthias Egger, Stuart J. Pocock, Peter C. Gøtzsche, and Jan P. Vandenbroucke. 2008. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Journal of Clinical Epidemiology 61: 344–349.

    Article  PubMed  Google Scholar 

  • Weed, Douglas L. 1988. Causal criteria and Popperian refutation. In Causal inference, ed. Kenneth J. Rothman, 15–32. Chestnut Hill, MA: Epidemiological Resources.

    Google Scholar 

  • Weed, Douglas L. 2004. Precaution, prevention, and public health ethics. Journal of Medicine and Philosophy 29 (3): 313–332.

    Article  PubMed  Google Scholar 

  • Weed, Douglas L. 2005. Methodologic implications of the precautionary principle: Causal criteria. Human and Ecological Risk Assessment 11: 107–113.

    Article  Google Scholar 

  • Weiss, Noel S. 2002. Can the ‘specificity’ of an association be rehabilitated as a basis for supporting a causal hypothesis? Epidemiology 13 (1): 6–8.

    Article  PubMed  Google Scholar 

  • Woodward, James. 2003. Making things happen: A theory of causal explanation. New York, NY: Oxford University Press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew Ward.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ward, A. Causal criteria and the problem of complex causation. Med Health Care and Philos 12, 333–343 (2009). https://doi.org/10.1007/s11019-009-9182-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11019-009-9182-2

Keywords

Navigation