Abstract
Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperitoneal administration of vehicle (control group) or Fen (6.25, 12.5 or 25 mg/kg) for 14 days; the animals were then subjected to habituation and object recognition tasks in open-field apparatus, and elevated plus-maze task. The administration of Fen (12.5 and 25 mg/kg) impaired habituation during the second exposure to the habituation task. In addition, the same doses of Fen also impaired the performance in object recognition task. In elevated plus-maze task, the administration of Fen (in all doses tested) induced anxiogenic-like effects in rats. Our results suggest that chronic Fen administration alters memory and induces anxiogenic-like effects in rats.
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Acknowledgments
This research was supported by grants from Programa de Pós-graduação em Ciências da Saúde—Universidade do Extremo Sul Catarinense (UNESC), Núcleo de Excelência em Neurociências Aplicadas de Santa Catarina NENASC project, Conselho Nacional de Desenvolvimento Científico e Tecnológico (PRONEX - FAPESC/CNPq), and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT).
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Gonçalves, C.L., Furlanetto, C.B., Valvassori, S.S. et al. Effects of chronic administration of fenproporex on cognitive and non-cognitive behaviors. Metab Brain Dis 30, 583–588 (2015). https://doi.org/10.1007/s11011-014-9617-1
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DOI: https://doi.org/10.1007/s11011-014-9617-1