Metabolic Brain Disease

, Volume 25, Issue 1, pp 73–80

Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence

Authors

    • Servei de Medicina Interna-HepatologiaHospital Universitari Vall d’Hebron
    • Departament de MedicinaUniversitat Autònoma de Barcelona
    • CIBERehd, Instituto de Salud Carlos III
  • Rita García-Martinez
    • Servei de Medicina Interna-HepatologiaHospital Universitari Vall d’Hebron
    • Departament de MedicinaUniversitat Autònoma de Barcelona
  • Macarena Simón-Talero
    • Servei de Medicina Interna-HepatologiaHospital Universitari Vall d’Hebron
    • Departament de MedicinaUniversitat Autònoma de Barcelona
Original Paper

DOI: 10.1007/s11011-010-9172-3

Cite this article as:
Córdoba, J., García-Martinez, R. & Simón-Talero, M. Metab Brain Dis (2010) 25: 73. doi:10.1007/s11011-010-9172-3

Abstract

Hyponatremic and hepatic encephalopathy are common causes of metabolic encephalopathy that may coexist in patients with cirrhosis. The clinical picture is common to any metabolic encephalopathy and is characterized by a confusional syndrome that may evolve into coma. Chronic mild or minimal manifestations can be seen in both, but motor symptoms are more common in hepatic encephalopathy. Recent advances show that in addition to clinical manifestations both encephalopathies share some pathogenetic mechanisms. Dysfunction of astrocytes, osmotic changes in the brain and brain edema are present in both situations. Recognition of these abnormalities is important to plan therapy. New drugs that affect brain hydration may be useful for both encephalopathies.

Keywords

Metabolic encephalopathyHepatic encephalopathyLiver failureCirrhosis complicationsHuman

Copyright information

© Springer Science+Business Media, LLC 2010