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miR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1

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Abstract

microRNAs (miRNAs) are small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. Reduced expression of miR-338 has been reported in several types of cancers; however, the role of miR-338 in oral squamous cell carcinoma (OSCC) has not been elucidated. In this study, we demonstrated that miR-338 was dramatically downregulated in OSCC tissues and cell lines. Overexpression of miR-338 significantly inhibited proliferation, colony formation, migration, and invasion of OSCC cells. In addition, neuropilin1 (NRP1) was identified as a target of miR-338 in OSCC cells and inversely correlated with miR-338 in OSCC tissues. Furthermore, restoration of NRP1 attenuated the tumor-suppressive effects of miR-338. Taken together, miR-338 might inhibit growth and metastasis of OSCC cells by targeting NRP1.

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Authors and Affiliations

  1. Department of Stomatology, Xi’an No.4 Hospital (The Affiliated Guangren Hospital of Xi’an Jiaotong University College Medicine), Xi’an, 710004, China

    Chunxi Liu, Yi Wang & Wuwei Gu

  2. Department of Stomatology, Hospital of Xi’an Jiaotong University, Xi’an, 710049, China

    Zhiyu Wang

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  1. Chunxi Liu
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  2. Zhiyu Wang
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  4. Wuwei Gu
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Correspondence to Chunxi Liu.

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Liu, C., Wang, Z., Wang, Y. et al. miR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1. Mol Cell Biochem 398, 115–122 (2015). https://doi.org/10.1007/s11010-014-2211-3

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  • DOI: https://doi.org/10.1007/s11010-014-2211-3

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