Molecular and Cellular Biochemistry

, Volume 387, Issue 1, pp 171–176

Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK

Article

DOI: 10.1007/s11010-013-1882-5

Cite this article as:
Lei, L., Huang, Y. & Gong, W. Mol Cell Biochem (2014) 387: 171. doi:10.1007/s11010-013-1882-5

Abstract

microRNAs play critical roles in the progression and metastasis of nonsmall cell lung cancer (NSCLC). miR-92b acts as an oncogene in some malignancies; however, its role in NSCLC remains poorly understood. Here, we found that miR-92b was significantly increased in human NSCLC tissues and cell lines. Inhibition of miR-92b remarkably suppressed cell proliferation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified to be a target of miR-92b. Expression of miR-92b was negatively correlated with RECK in NSCLC tissues. Collectively, miR-92b might promote NSCLC cell growth and motility partially by inhibiting RECK.

Keywords

miR-92Nonsmall cell lung cancerGrowthMigrationInvasion

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of OncologyXiangyang Central HospitalXiangyangChina
  2. 2.Department of Respiratory MedicineXiangyang Central HospitalXiangyangChina
  3. 3.Institute of OncologyMedical College of Hubei University of Arts and ScienceXiangyangChina