Date: 17 Aug 2013
A Lifecourse Approach to Health Development: Implications for the Maternal and Child Health Research Agenda
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Lifecourse-informed models of health fundamentally challenge simple biomedical models, introducing new ways of thinking about how diseases develop. This paper considers the broad implications of lifecourse theory for the maternal and child health (MCH) research agenda. The Lifecourse Health Development model provides an organizing framework for a synthesis of the existing literature on lifecourse health and identification of gaps in knowledge. Priority areas identified for MCH research in order to close these knowledge gaps include: epigenetic mechanisms and their potential mutability; peri-conception as a critical and sensitive period for environmental exposures; maternal health prior to pregnancy; the role of the placenta as an important regulator of the intra-uterine environment; and ways to strengthen early mother–child interactions. Addressing knowledge gaps will require an emphasis on longitudinal rather than cross-sectional studies, long-term (lifetime) rather than short-term perspectives, datasets that include socio-demographic, biologic and genetic data on the same subjects rather than discipline-specific studies, measurement and study of positive health as well as disease states, and study of multi-rather than single generational cohorts. Adoption of a lifecourse-informed MCH research agenda requires a shift in focus from single cause-single disease epidemiologic inquiry to one that addresses multiple causes and outcomes. Investigators need additional training in effective interdisciplinary collaboration, advanced research methodology and higher-level statistical modeling. Advancing a life course health development research agenda in MCH will be foundational to the nation’s long-term health.
Elder, G. H. (1998). The life course as developmental theory. Child Development, 69(1), 1–12.PubMed
Elder, G. H., Johnson, M. K., & Crosnoe, R. (2003). The emergence and development of life course theory. In J. T. Mortimer & M. J. Shanahan (Eds.), Handbook of the life course. New York: Kluwer Academic/Plenum Publishers.
Wadsworth, M. E. J. (1999). Early life. In M. Marmot & R. G. Wilkinson (Eds.), Social determinants of health (pp. 44–63). New York: Oxford Press.
Acheson, D., Barker, D., Chamber, J., et al. (1998). Report of the independent inquiry into inequalities in health (the acheson report). London: The Stationary Office.
Aylot, J., Brown, I., Copeland, R., et al. (2008). Tackling obesities: The Foresight Report and implications for local government. Sheffield, South Yorkshire: Sheffield Hallam University, Faculty of Health and Wellbeing.
Foresight Mental Capital and Wellbeing Project. (2008). Final project report—executive summary. London: The Government Office for Science.
Marmot, M. (2010). The Marmot review: Strategic review of health inequalities in England post-2010. London: The Marmot Review.
Committee on Breast Cancer and the Environment, Institute of Medicine. (2011). Breast cancer and the environment: A life course approach. Washington, DC: Institute of Medicine of the National Academy of Sciences. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2011/Breast-Cancer-Environment/BreastCancerReportbrief_2.pdf.
Committee on Leading Health Indicators for Healthy People 2020, Institute of Medicine. (2011). Leading health indicators for Healthy People 2020: Letter report. Washington, DC: Institute of Medicine of the National Academy of Sciences. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2011/Leading-Health-Indicators-for-Healthy-People-2020/Leading%20Health%20Indicators%202011%20Report%20Brief.pdf.
Hertzman, C. (1994). The lifelong impact of childhood experiences—a population health perspective. Daedalus, 123(4), 167–180.
Hertzman, C. (1999). The biological embedding of early experience and its effects on health in adulthood. Annals New York Academy of Sciences, 896, 85–95.CrossRef
Halfon, N., Russ, S. A., & Regalado, M. (2005). The life course health development model: A guide to children’s health care policy and practice. Zero to Three, 25(3), 4–12.
Schonkoff, J. P., Boyce, W. T., & McEwan, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. The Journal of the American Medical Association, 301(21), 2252–2259.CrossRef
Fine, A., & Kotelchuck, M. (2010). Rethinking MCH: The life course model as an organizing framework. Washington, DC: U.S. Department of Health and Human Services Health Resources and Services Administration, Maternal and Child Health Bureau. Available at: http://mchb.hrsa.gov/lifecourse/rethinkingmchlifecourse.pdf.
Halfon, N., Inkelas, M., & Hochstein, M. (2000). The health development organization: An organizational approach to achieving child health development. The Milbank Quarterly, 78(3), 447–497 (341).
Institute of Medicine. (2004). Children’s health, the nation’s wealth. Washington, DC: The National Academies Press.
Hertzman, C., & Boyce, T. (2010). How experience gets under the skin to create gradients in developmental health. Annual Review of Public Health, 31, 329–347 (3p following 47).
Noble, K. G., Houston, S. M., Kan, E., et al. (2012). Neural correlates of socioeconomic status in the developing human brain. Developmental Science, 1–12.
Michels, K. B., & Waterland, M. R. (2012). The role of epigenetics in the developmental origins of health and disease. In K. B. Michels (Ed.), Epigenetic epidemiology (pp. 105–116). New York: Springer.CrossRef
Breslau, N. (1995). Psychiatric sequelae of low birth weight. Epidemiologic Reviews, 17(1), 96–106.PubMed
Bromer, C., Marsit, C. J., & Armstrong, D. A., et al. (2012). Genetic and epigenetic variation of the glucocorticoid receptor (nr3c1) in placenta and infant neurobehavior. Developmental Psychobiology.
Gluckman, P. D., Hanson, M. A., & Buklijas, T. (2010). A conceptual framework for the developmental origins of health and disease. Journal of Developmental Origins of Health and Disease, 1(01), 6–18.CrossRef
Liu, S., Jones, R. N., & Glymour, M. M. (2010). Implications of lifecourse epidemiology for research on determinants of adult disease. Public Health Review, 32(2), 489–511.
Moffitt, T. E. (2005). Genetic and environmental influences on antisocial behaviors: Evidence from behavioral-genetic research. Advances in Genetics, 55, 41–104.PubMed
Jokela, M., Lehtimaki, T., & Keltikangas-Jarvinen, L. (2007). The influence of urban/rural residency on depressive symptoms is moderated by the serotonin receptor 2a gene. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, 144B(7), 918–922.CrossRef
Gilbert, S. F. (2000). Developmental biology (6th ed.). Sunderland, MA: Sinauer Associates.
Connor, N. E. (2011). Impact of fetal and neonatal malnutrition on the onset of puberty and associated noncommunicable disease risks. Adolescent Health, Medicine and Therapeutics, 2011, 15–25.CrossRef
Wilkinson, R. G., & Pickett, K. E. (2009). The spirit level: Why equality is better for everyone. New York: Bloomsbury Press.
Goldman, D. P., Shang, B., Bhattacharya, J., et al. (2005). Consequences of health trends and medical innovation for the future elderly. Health Affairs, 24(Suppl 2), W5R5–W5R17.PubMed
- A Lifecourse Approach to Health Development: Implications for the Maternal and Child Health Research Agenda
Maternal and Child Health Journal
Volume 18, Issue 2 , pp 497-510
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Health development
- Maternal and child health
- Industry Sectors
- Author Affiliations
- 1. UCLA Center for Healthier Children, Families, and Communities, 10990 Wilshire Blvd, Suite 900, Los Angeles, CA, 90024, USA
- 2. Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
- 3. Department of Health Services, School of Public Health, UCLA, Los Angeles, CA, USA
- 4. Department of Public Policy, School of Public Affairs, UCLA, Los Angeles, CA, USA