Abstract
Objectives Very-low-birthweight (VLBW) delivery accounts for the majority of neonatal mortality and the black–white disparity in infant mortality. The risk of recurrent VLBW is highest for African-Americans of lower socioeconomic status. This study explores whether the provision of primary health care and social support following a VLBW delivery improves subsequent child spacing and pregnancy outcomes for low-income, African-American women. Methods This pilot study of mixed prospective-retrospective cohort design enrolled African-American women who qualified for indigent care and delivered a VLBW infant at a public hospital in Atlanta from November 2003 through March 2004 into the intervention cohort (n 1 = 29). The intervention consisted of coordinated primary health care and social support for 24 months following the VLBW delivery. A retrospective cohort was assembled from consecutive women meeting the same eligibility criteria who delivered a VLBW infant during July 2001 through June 2002 (n 2 = 58). The number of pregnancies conceived within 18 months of the index VLBW delivery and the number of adverse pregnancy outcomes for each cohort was compared with Poisson regression. Results Women in the control cohort had, on average, 2.6 (95% CI: 1.1–5.8) times as many pregnancies within 18 months of the index VLBW delivery and 3.5 (95% CI: 1.0–11.7) times as many adverse pregnancy outcomes as women in the intervention cohort. Conclusions This small, pilot study suggests that primary health care and social support for low-income, African-American women following a VLBW delivery may enhance achievement of a subsequent 18-month interpregnancy interval and reduce adverse pregnancy outcomes.
Similar content being viewed by others
References
Alexander, G. R., Kogan, M., Bader, D., Carlo, W., Allen, M., & Mor, J. (2003). U.S. birth weight/gestational age-specific mortality: 1995–1997 rates for whites, Hispanics, and blacks. Pediatrics, 111(1), e61–e66.
Iyasu, S., Becerra, J. E., Rowley, D. L., & Hogue, C. J. (1992). Impact of very low birth weight on the black-white infant mortality gap. American Journal of Preventive Medicine, 8, 271–277.
Parham, G. P., & Hicks, M. L. (2005). Racial disparities affecting the reproductive health of African-American women. The Medical Clinics of North America, 89, 935–943.
Adams, M. M., Elam-Evans, L. D., Wilson, H. G., & Gilbertz, D. A. (2000). Rates of and factors associated with recurrence of preterm delivery. The Journal of American Medical Association, 283, 1591–1596.
Surkan, P. J., Stephansson, O., Dickman, P. W., & Cnattingius, S. (2004). Previous preterm and small-for-gestational-age births and the subsequent risk of stillbirth. The New England Journal of Medicine, 350(8), 777–785.
Kovilam, O., Khoury, J., Miodovnik, M., Chames, M., Spinnoto, J., & Sibai, B. (2002). Spontaneous preterm delivery in the type 1 diabetic pregnancy: The role of glycemic control. The Journal of Maternal Fetal & Neonatal Medicine, 11, 245–248.
Sibai, B., Caritis, S. N., Hauth, J. C., MacPherson, C., VanDorsten, J. P., & Klebanoff, M. (2000). Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies. American Journal of Obstetrics and Gynecology, 183, 1520–1524.
Lockwood, C. J. (1999). Heritable coagulopathies in pregnancy. Obstetrical & Gynecological Survey, 54, 754–759.
Jacobsson, B., Pernevi, P., Chidekel, L., & Platz-Christensen, J. J. (2002). Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis. Acta Obstetricia et Gynecologica Scandinavica, 81, 1006–1010.
Offenbacher, S., Lieff, S., Boggess, K. A., Murtha, A. P., Madianos, P. N., Champagne, C. M., et al. (2001). Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Annals of Periodontology, 6, 164–174.
Madianos, P. N., Lieff, S., Murtha, A. P., Boggess, K. A., Auten, R. L., Beck, J. D., et al. (2001). Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Annals of Periodontology, 6, 175–182.
Cnattingius, S., Bergstrom, R., Lipworth, L., & Kramer, M. S. (1998). Pre-pregnancy weight and the risk of adverse pregnancy outcomes. The New England Journal of Medicine, 338, 147–152.
Sebire, N. J., Jolly, M., Harris, J., Regan, L., & Robinson, S. (2001). Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London. British Journal of Obstetrics and Gynecology, 108, 61–66.
Xiong, X., Buekens, P., Alexander, S., Demianczuk, N., & Wollast, E. (2000). Anemia during pregnancy and birth outcome: A meta-analysis. American Journal of Perinatology, 17, 137–146.
Scanlon, K. S., Yip, R., Schieve, L. A., & Cogswell, M. E. (2000). High and low hemoglobin levels during pregnancy: Differential risks for preterm birth and small for gestational age. Obstetrics and Gynecology, 96, 741–748.
Kelly, R. H., Russo, J., Holt, V. L., Danielsen, B. H., Zatzick, D. F., Walker, E., et al. (2002). Psychiatric and substance use disorders as risk factors for low birth weight and preterm delivery. Obstetrics and Gynecology, 100, 297–304.
Wadha, P. D., Culhane, J. F., Rauh, V., Barve, S. S., Hogan, V., Sandman, C. A., et al. (2001). Stress, infection and preterm birth: A biobehavioural perspective. Paediatric and Perinatal Epidemiology, 15, 17–29.
Orr, S. T., James, S. A., & Blackmore-Prince, C. (2002). Maternal prenatal depressive symptoms and spontaneous preterm births among African-American women in Baltimore, Maryland. American Journal of Epidemiology, 156, 797–802.
Klerman, L. V., Cliver, S. P., & Goldenberg, R. L. (1998). The impact of short interpregnancy intervals on pregnancy outcomes in a low-income population. American Journal of Public Health, 88, 1182–1185.
Conde-Agudelo, A., Rosas-Bermudez, A., & Kafury-Goeta, A. (2006). Birth spacing and risk of adverse perinatal outcomes: A meta-analysis. The Journal of American Medical Association, 295, 1809–1823.
Goldenberg, R. L., Iams, J. D., Mercer, B. M., Meis, P. J., Moawad, A. H., & Copper, R. L. (1998). The preterm prediction study: The value of new vs. standard risk factors in predicting early and all spontaneous preterm births. American Journal of Public Health, 88, 233–238.
Lockwood, C. J. (2002). Predicting premature delivery – no easy task. The New England Journal of Medicine, 346, 282–284.
Andrews, W. W., & Goldenberg, R. L. (2003). What we have learned from an antibiotic trial in fetal fibronectin positive women. Seminars in Perinatology, 27, 231–238.
Meis, P. J., Klebanoff, M. A., Thorn, E., Dombroski, M. P., Sibai, B., et al. (2003). Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. The New England Journal of Medicine, 348, 2379–2385.
American College of Obstetrics, Gynecology (ACOG). (2003). Use of progesterone to reduce preterm birth. ACOG Committee Opinion No. 291. Obstetrics and Gynecology, 102, 1115–1116.
Hauth, J. C., Goldenberg, R. L., Andrews, W. W., DuBard, M. B., & Cooper, R. L. (1995). Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. The New England Journal of Medicine, 333, 1732–1736.
Morales, W. J., Schorr, S., & Albritton, J. (1994). Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study. American Journal of Obstetrics and Gynecology, 171, 345–349.
Vermeulen, G. M., & Bruinse, H. W. (1999). Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: A randomised placebo-controlled double-blind trial. British Journal of Obstetrics and Gynecology, 106, 652–657.
Carey, J. C. (2000). Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. The New England Journal of Medicine, 342, 534–540.
Odendaal, H. J., Popov, I., Schoeman, J., Smith, M., & Grove, D. (2002). Preterm labor – is bacterial vaginosis involved? South African Medical Journal, 92, 231–234.
Ugwumadu, A., Manyonda, I., Reid, F., & Hay, P. (2003). Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: A randomised controlled trial. Lancet, 361, 983–988.
Andrews, W. W., Goldeberg, R. L., Hauth, J. C., Cliver, S. P., Copper, R. C., & Conner, M. (2006). Interconceptional antibiotics to prevent spontaneous preterm birth: A randomized clinical trial. American Journal of Obstetrics and Gynecology, 194, 617–623.
PORT. (2000). Findings from the 1992–98 patient outcomes research team on low birth weight. Clinical Highlight. Rockville, MD: Agency for Healthcare Research and Quality.
Centers for Disease Control and Prevention. (2006). Recommendations to improve preconception health and health care – United States: A report of the CDC/ATSDR Preconception Care Work Group and the select panel on preconception care. Morbidity and Mortality Weekly Report, 55(RR-6), 1–25.
Georgia Perinatal Task Force. (1998). Georgia Perinatal Task Force Report on the regional perinatal health care delivery system – assessment and recommendations. Atlanta, Georgia: World Health Organization Collaborating Center in Reproductive Health.
Biermann, J., Dunlop, A. L., Brady, C., Dubin, C., & Brann, A. W. (2006). Promising practices in preconception care for women at risk for poor health and pregnancy outcomes. Maternal and Child Health Journal, 10(Suppl 7), 21–28.
Rising, S. S. (1998). Centering pregnancy. An interdisciplinary model of empowerment. Journal of Nurse Midwifery, 43, 46–54.
Valero, J., Soriano, T., Albaladejo, R., Juarranz, M., Calle, M., Martinez, D., et al. (2004). Risk factors for low birth weight: A review. European Journal of Obstetrics, Gynecology and Reproductive Biology, 116, 3–15.
Slattery, M. M., & Morrison, J. J. (2002). Preterm delivery. Lancet, 360, 1489–1497.
Fretts, R. C. (2005). Etiology and prevention of stillbirth. American Journal of Obstetrics and Gynecology, 193, 1923–1935.
Garcia-Enguidanos, A., Calle, M. E., Valero, J., Luna, S., & Dominguez-Rojas, V. (2002). Risk factors in miscarriage: A review. European Journal of Obstetrics, Gynecology and Reproductive Biology, 102, 111–119.
Berkowitz, R. S., Cramer, D. W., Bernstein, M. R., Cassells, S., Driscoll, S. G., & Goldstein, D. P. (1985). Risk factors for complete molar pregnancy from a case-control study. American Journal of Obstetrics and Gynecology, 152, 1016–1020.
Ankum, W. M., Mol, B. W.J, Van der Veen, F., & Bnossuyt, P. M. (1996). Risk factors for ectopic pregnancy: A meta analysis. Fertility and Sterility, 65, 1093–1099.
Centers for Disease Control, Prevention (CDC). (2003). Behavioral risk factor surveillance system survey questionnaire. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.
Rosner, B. (1995). Discrete probability distributions. The expected value of a discrete random variable. In Fundamentals of biostatistics (4th ed., p. 75). New York: Duxbury Press.
Higgins, J. P. T., & Green, S. (Eds.). (2005). Effect measures for counts and rates. Cochrane handbook for systematic reviews of interventions 8.2.4 [updated May 2005]; Section 8. In The Cochrane Library (Issue 3). Chichester, UK: Wiley.
Rothman, K., & Greenland, S. (1994). Modern epidemiology (2nd ed., p. 256). Philadelphia: Lippincott Williams, & Wilkins.
Kaiser Family Foundation. (2004). Medicaid’s role for women: Issue brief on women’s health policy. Washington, DC: Kaiser Family Foundation.
Kaiser Family Foundation. (2005). Medicaid: A critical source of support for family planning in the United States: Issue brief on women’s health policy. Washington, DC: Kaiser Family Foundation.
Klerman, L. V., Ramey, S. L., Goldenberg, R. L., Marbury, S., Hou, J., & Cliver, S. P. (2001). A randomized trial of augmented prenatal care for multiple-risk, medicaid-eligible African American women. American Journal of Public Health, 91, 105–111.
Goldenberg, R. L., & Culhane, J. F. (2005). Prepregnancy health status and the risk of preterm delivery. Archives of Pediatrics & Adolescent Medicine, 159, 89–90.
Acknowledgements
We gratefully acknowledge Ms. Michelle McIntosh and Ms. Patricia Ward who served as the nurse case manager and Resource Mother for this study. Funding and support for the conduct of this research study was provided by Vasser-Woolley Foundation, Grady Memorial Hospital, Healthcare Georgia Foundation, Centers for Disease Control and Prevention, Rockdale Foundation, Smith Family Foundation, March of Dimes, and the General Clinical Research Center at Emory University funded by the National Center for Research Resources (NCRR M01-RR00039).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dunlop, A.L., Dubin, C., Raynor, B.D. et al. Interpregnancy Primary Care and Social Support for African-American Women at Risk for Recurrent Very-low-birthweight Delivery: A Pilot Evaluation. Matern Child Health J 12, 461–468 (2008). https://doi.org/10.1007/s10995-007-0279-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10995-007-0279-z