Skip to main content

Advertisement

Log in

Interpregnancy Primary Care and Social Support for African-American Women at Risk for Recurrent Very-low-birthweight Delivery: A Pilot Evaluation

  • Published:
Maternal and Child Health Journal Aims and scope Submit manuscript

Abstract

Objectives Very-low-birthweight (VLBW) delivery accounts for the majority of neonatal mortality and the black–white disparity in infant mortality. The risk of recurrent VLBW is highest for African-Americans of lower socioeconomic status. This study explores whether the provision of primary health care and social support following a VLBW delivery improves subsequent child spacing and pregnancy outcomes for low-income, African-American women. Methods This pilot study of mixed prospective-retrospective cohort design enrolled African-American women who qualified for indigent care and delivered a VLBW infant at a public hospital in Atlanta from November 2003 through March 2004 into the intervention cohort (n 1 = 29). The intervention consisted of coordinated primary health care and social support for 24 months following the VLBW delivery. A retrospective cohort was assembled from consecutive women meeting the same eligibility criteria who delivered a VLBW infant during July 2001 through June 2002 (n 2 = 58). The number of pregnancies conceived within 18 months of the index VLBW delivery and the number of adverse pregnancy outcomes for each cohort was compared with Poisson regression. Results Women in the control cohort had, on average, 2.6 (95% CI: 1.1–5.8) times as many pregnancies within 18 months of the index VLBW delivery and 3.5 (95% CI: 1.0–11.7) times as many adverse pregnancy outcomes as women in the intervention cohort. Conclusions This small, pilot study suggests that primary health care and social support for low-income, African-American women following a VLBW delivery may enhance achievement of a subsequent 18-month interpregnancy interval and reduce adverse pregnancy outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Alexander, G. R., Kogan, M., Bader, D., Carlo, W., Allen, M., & Mor, J. (2003). U.S. birth weight/gestational age-specific mortality: 1995–1997 rates for whites, Hispanics, and blacks. Pediatrics, 111(1), e61–e66.

    Article  PubMed  Google Scholar 

  2. Iyasu, S., Becerra, J. E., Rowley, D. L., & Hogue, C. J. (1992). Impact of very low birth weight on the black-white infant mortality gap. American Journal of Preventive Medicine, 8, 271–277.

    PubMed  CAS  Google Scholar 

  3. Parham, G. P., & Hicks, M. L. (2005). Racial disparities affecting the reproductive health of African-American women. The Medical Clinics of North America, 89, 935–943.

    Article  PubMed  Google Scholar 

  4. Adams, M. M., Elam-Evans, L. D., Wilson, H. G., & Gilbertz, D. A. (2000). Rates of and factors associated with recurrence of preterm delivery. The Journal of American Medical Association, 283, 1591–1596.

    Article  CAS  Google Scholar 

  5. Surkan, P. J., Stephansson, O., Dickman, P. W., & Cnattingius, S. (2004). Previous preterm and small-for-gestational-age births and the subsequent risk of stillbirth. The New England Journal of Medicine, 350(8), 777–785.

    Article  PubMed  CAS  Google Scholar 

  6. Kovilam, O., Khoury, J., Miodovnik, M., Chames, M., Spinnoto, J., & Sibai, B. (2002). Spontaneous preterm delivery in the type 1 diabetic pregnancy: The role of glycemic control. The Journal of Maternal Fetal & Neonatal Medicine, 11, 245–248.

    Article  CAS  Google Scholar 

  7. Sibai, B., Caritis, S. N., Hauth, J. C., MacPherson, C., VanDorsten, J. P., & Klebanoff, M. (2000). Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies. American Journal of Obstetrics and Gynecology, 183, 1520–1524.

    Article  PubMed  CAS  Google Scholar 

  8. Lockwood, C. J. (1999). Heritable coagulopathies in pregnancy. Obstetrical & Gynecological Survey, 54, 754–759.

    Article  CAS  Google Scholar 

  9. Jacobsson, B., Pernevi, P., Chidekel, L., & Platz-Christensen, J. J. (2002). Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis. Acta Obstetricia et Gynecologica Scandinavica, 81, 1006–1010.

    Article  PubMed  Google Scholar 

  10. Offenbacher, S., Lieff, S., Boggess, K. A., Murtha, A. P., Madianos, P. N., Champagne, C. M., et al. (2001). Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Annals of Periodontology, 6, 164–174.

    Article  PubMed  CAS  Google Scholar 

  11. Madianos, P. N., Lieff, S., Murtha, A. P., Boggess, K. A., Auten, R. L., Beck, J. D., et al. (2001). Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Annals of Periodontology, 6, 175–182.

    Article  PubMed  CAS  Google Scholar 

  12. Cnattingius, S., Bergstrom, R., Lipworth, L., & Kramer, M. S. (1998). Pre-pregnancy weight and the risk of adverse pregnancy outcomes. The New England Journal of Medicine, 338, 147–152.

    Article  PubMed  CAS  Google Scholar 

  13. Sebire, N. J., Jolly, M., Harris, J., Regan, L., & Robinson, S. (2001). Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London. British Journal of Obstetrics and Gynecology, 108, 61–66.

    Article  CAS  Google Scholar 

  14. Xiong, X., Buekens, P., Alexander, S., Demianczuk, N., & Wollast, E. (2000). Anemia during pregnancy and birth outcome: A meta-analysis. American Journal of Perinatology, 17, 137–146.

    Article  PubMed  CAS  Google Scholar 

  15. Scanlon, K. S., Yip, R., Schieve, L. A., & Cogswell, M. E. (2000). High and low hemoglobin levels during pregnancy: Differential risks for preterm birth and small for gestational age. Obstetrics and Gynecology, 96, 741–748.

    Article  PubMed  CAS  Google Scholar 

  16. Kelly, R. H., Russo, J., Holt, V. L., Danielsen, B. H., Zatzick, D. F., Walker, E., et al. (2002). Psychiatric and substance use disorders as risk factors for low birth weight and preterm delivery. Obstetrics and Gynecology, 100, 297–304.

    Article  PubMed  Google Scholar 

  17. Wadha, P. D., Culhane, J. F., Rauh, V., Barve, S. S., Hogan, V., Sandman, C. A., et al. (2001). Stress, infection and preterm birth: A biobehavioural perspective. Paediatric and Perinatal Epidemiology, 15, 17–29.

    Article  Google Scholar 

  18. Orr, S. T., James, S. A., & Blackmore-Prince, C. (2002). Maternal prenatal depressive symptoms and spontaneous preterm births among African-American women in Baltimore, Maryland. American Journal of Epidemiology, 156, 797–802.

    Article  PubMed  Google Scholar 

  19. Klerman, L. V., Cliver, S. P., & Goldenberg, R. L. (1998). The impact of short interpregnancy intervals on pregnancy outcomes in a low-income population. American Journal of Public Health, 88, 1182–1185.

    PubMed  CAS  Google Scholar 

  20. Conde-Agudelo, A., Rosas-Bermudez, A., & Kafury-Goeta, A. (2006). Birth spacing and risk of adverse perinatal outcomes: A meta-analysis. The Journal of American Medical Association, 295, 1809–1823.

    Article  CAS  Google Scholar 

  21. Goldenberg, R. L., Iams, J. D., Mercer, B. M., Meis, P. J., Moawad, A. H., & Copper, R. L. (1998). The preterm prediction study: The value of new vs. standard risk factors in predicting early and all spontaneous preterm births. American Journal of Public Health, 88, 233–238.

    Article  PubMed  CAS  Google Scholar 

  22. Lockwood, C. J. (2002). Predicting premature delivery – no easy task. The New England Journal of Medicine, 346, 282–284.

    Article  PubMed  Google Scholar 

  23. Andrews, W. W., & Goldenberg, R. L. (2003). What we have learned from an antibiotic trial in fetal fibronectin positive women. Seminars in Perinatology, 27, 231–238.

    Article  PubMed  Google Scholar 

  24. Meis, P. J., Klebanoff, M. A., Thorn, E., Dombroski, M. P., Sibai, B., et al. (2003). Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. The New England Journal of Medicine, 348, 2379–2385.

    Article  PubMed  CAS  Google Scholar 

  25. American College of Obstetrics, Gynecology (ACOG). (2003). Use of progesterone to reduce preterm birth. ACOG Committee Opinion No. 291. Obstetrics and Gynecology, 102, 1115–1116.

    Article  Google Scholar 

  26. Hauth, J. C., Goldenberg, R. L., Andrews, W. W., DuBard, M. B., & Cooper, R. L. (1995). Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. The New England Journal of Medicine, 333, 1732–1736.

    Article  PubMed  CAS  Google Scholar 

  27. Morales, W. J., Schorr, S., & Albritton, J. (1994). Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study. American Journal of Obstetrics and Gynecology, 171, 345–349.

    PubMed  CAS  Google Scholar 

  28. Vermeulen, G. M., & Bruinse, H. W. (1999). Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: A randomised placebo-controlled double-blind trial. British Journal of Obstetrics and Gynecology, 106, 652–657.

    CAS  Google Scholar 

  29. Carey, J. C. (2000). Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. The New England Journal of Medicine, 342, 534–540.

    Article  PubMed  CAS  Google Scholar 

  30. Odendaal, H. J., Popov, I., Schoeman, J., Smith, M., & Grove, D. (2002). Preterm labor – is bacterial vaginosis involved? South African Medical Journal, 92, 231–234.

    PubMed  CAS  Google Scholar 

  31. Ugwumadu, A., Manyonda, I., Reid, F., & Hay, P. (2003). Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: A randomised controlled trial. Lancet, 361, 983–988.

    Article  PubMed  CAS  Google Scholar 

  32. Andrews, W. W., Goldeberg, R. L., Hauth, J. C., Cliver, S. P., Copper, R. C., & Conner, M. (2006). Interconceptional antibiotics to prevent spontaneous preterm birth: A randomized clinical trial. American Journal of Obstetrics and Gynecology, 194, 617–623.

    Article  PubMed  CAS  Google Scholar 

  33. PORT. (2000). Findings from the 1992–98 patient outcomes research team on low birth weight. Clinical Highlight. Rockville, MD: Agency for Healthcare Research and Quality.

  34. Centers for Disease Control and Prevention. (2006). Recommendations to improve preconception health and health care – United States: A report of the CDC/ATSDR Preconception Care Work Group and the select panel on preconception care. Morbidity and Mortality Weekly Report, 55(RR-6), 1–25.

    Google Scholar 

  35. Georgia Perinatal Task Force. (1998). Georgia Perinatal Task Force Report on the regional perinatal health care delivery system – assessment and recommendations. Atlanta, Georgia: World Health Organization Collaborating Center in Reproductive Health.

  36. Biermann, J., Dunlop, A. L., Brady, C., Dubin, C., & Brann, A. W. (2006). Promising practices in preconception care for women at risk for poor health and pregnancy outcomes. Maternal and Child Health Journal, 10(Suppl 7), 21–28.

    Article  Google Scholar 

  37. Rising, S. S. (1998). Centering pregnancy. An interdisciplinary model of empowerment. Journal of Nurse Midwifery, 43, 46–54.

    Article  PubMed  CAS  Google Scholar 

  38. Valero, J., Soriano, T., Albaladejo, R., Juarranz, M., Calle, M., Martinez, D., et al. (2004). Risk factors for low birth weight: A review. European Journal of Obstetrics, Gynecology and Reproductive Biology, 116, 3–15.

    Article  Google Scholar 

  39. Slattery, M. M., & Morrison, J. J. (2002). Preterm delivery. Lancet, 360, 1489–1497.

    Article  PubMed  Google Scholar 

  40. Fretts, R. C. (2005). Etiology and prevention of stillbirth. American Journal of Obstetrics and Gynecology, 193, 1923–1935.

    Article  PubMed  Google Scholar 

  41. Garcia-Enguidanos, A., Calle, M. E., Valero, J., Luna, S., & Dominguez-Rojas, V. (2002). Risk factors in miscarriage: A review. European Journal of Obstetrics, Gynecology and Reproductive Biology, 102, 111–119.

    Article  CAS  Google Scholar 

  42. Berkowitz, R. S., Cramer, D. W., Bernstein, M. R., Cassells, S., Driscoll, S. G., & Goldstein, D. P. (1985). Risk factors for complete molar pregnancy from a case-control study. American Journal of Obstetrics and Gynecology, 152, 1016–1020.

    PubMed  CAS  Google Scholar 

  43. Ankum, W. M., Mol, B. W.J, Van der Veen, F., & Bnossuyt, P. M. (1996). Risk factors for ectopic pregnancy: A meta analysis. Fertility and Sterility, 65, 1093–1099.

    PubMed  CAS  Google Scholar 

  44. Centers for Disease Control, Prevention (CDC). (2003). Behavioral risk factor surveillance system survey questionnaire. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.

    Google Scholar 

  45. Rosner, B. (1995). Discrete probability distributions. The expected value of a discrete random variable. In Fundamentals of biostatistics (4th ed., p. 75). New York: Duxbury Press.

  46. Higgins, J. P. T., & Green, S. (Eds.). (2005). Effect measures for counts and rates. Cochrane handbook for systematic reviews of interventions 8.2.4 [updated May 2005]; Section 8. In The Cochrane Library (Issue 3). Chichester, UK: Wiley.

  47. Rothman, K., & Greenland, S. (1994). Modern epidemiology (2nd ed., p. 256). Philadelphia: Lippincott Williams, & Wilkins.

  48. Kaiser Family Foundation. (2004). Medicaid’s role for women: Issue brief on women’s health policy. Washington, DC: Kaiser Family Foundation.

    Google Scholar 

  49. Kaiser Family Foundation. (2005). Medicaid: A critical source of support for family planning in the United States: Issue brief on women’s health policy. Washington, DC: Kaiser Family Foundation.

    Google Scholar 

  50. Klerman, L. V., Ramey, S. L., Goldenberg, R. L., Marbury, S., Hou, J., & Cliver, S. P. (2001). A randomized trial of augmented prenatal care for multiple-risk, medicaid-eligible African American women. American Journal of Public Health, 91, 105–111.

    PubMed  CAS  Google Scholar 

  51. Goldenberg, R. L., & Culhane, J. F. (2005). Prepregnancy health status and the risk of preterm delivery. Archives of Pediatrics & Adolescent Medicine, 159, 89–90.

    Article  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge Ms. Michelle McIntosh and Ms. Patricia Ward who served as the nurse case manager and Resource Mother for this study. Funding and support for the conduct of this research study was provided by Vasser-Woolley Foundation, Grady Memorial Hospital, Healthcare Georgia Foundation, Centers for Disease Control and Prevention, Rockdale Foundation, Smith Family Foundation, March of Dimes, and the General Clinical Research Center at Emory University funded by the National Center for Research Resources (NCRR M01-RR00039).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anne Lang Dunlop.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dunlop, A.L., Dubin, C., Raynor, B.D. et al. Interpregnancy Primary Care and Social Support for African-American Women at Risk for Recurrent Very-low-birthweight Delivery: A Pilot Evaluation. Matern Child Health J 12, 461–468 (2008). https://doi.org/10.1007/s10995-007-0279-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10995-007-0279-z

Keywords

Navigation