Abstract
Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.
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Acknowledgments
The research was supported by the Danish Natural Science Research Council [grant number 272-06-0442 “Point process modeling and statistical inference”]. We are grateful to CIBMTR for providing us with the example data [Public Health Service Grant/Cooperative Agreement No. U24-CA76518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID)].
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Binder, N., Gerds, T.A. & Andersen, P.K. Pseudo-observations for competing risks with covariate dependent censoring. Lifetime Data Anal 20, 303–315 (2014). https://doi.org/10.1007/s10985-013-9247-7
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DOI: https://doi.org/10.1007/s10985-013-9247-7