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Comparative thermal stability of two similar-structure hypolipidemic agents

Simvastatin and Lovastatin—kinetic study

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Abstract

Simvastatin (SIM) and lovastatin (LOV) are two important active pharmaceutical ingredients from statin class, prescribed in the treatment of hypercholesterolemia. Our study presents the results obtained by our research group regarding the decomposition of SIM and LOV in oxidative atmosphere, by employing three isoconversional methods, namely Friedman, Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa. The results obtained by Friedman method suggested a multistep degradation, while the ones obtained by Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa suggested a single-step degradation. In order to validate the results, we used the NPK method, which allowed a concrete separation and nature of processes that contributed to the degradation of both statins. NPK method showed that both SIM and LOV are degraded by contribution of two distinctive chemical processes, and the mean values of activation energies are also reported.

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Acknowledgements

This work was performed at West University of Timişoara and was supported by the strategic Grant POSDRU/159/1.5/S/137750, Project “Doctoral and Postdoctoral programs support for increased competitiveness in Exact Sciences research” co-financed by the “European Social Fund within the Sectoral Operational Programme Human Resources Development 2007–2013” to Ionuţ Ledeţi.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Chemistry-Biology-Geography, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Ionuţ Ledeţi, Gabriela Vlase & Titus Vlase

  2. Research Center for Thermal Analysis in Environmental Problems, Faculty of Chemistry-Biology-Geography, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Ionuţ Ledeţi, Gabriela Vlase & Titus Vlase

  3. Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Ionuţ Ledeţi, Adriana Fuliaş & Lenuţa-Maria Şuta

Authors
  1. Ionuţ Ledeţi
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  2. Gabriela Vlase
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  3. Titus Vlase
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  4. Adriana Fuliaş
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  5. Lenuţa-Maria Şuta
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Correspondence to Adriana Fuliaş.

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Ledeţi, I., Vlase, G., Vlase, T. et al. Comparative thermal stability of two similar-structure hypolipidemic agents. J Therm Anal Calorim 125, 769–775 (2016). https://doi.org/10.1007/s10973-015-5071-5

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  • DOI: https://doi.org/10.1007/s10973-015-5071-5

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