Abstract
Melting of betulin dipropionate (3β,28-di-O-propionyl-lup-20(29)-lupene) of high purity (orthorhombic P212121, a = 1.27409(2), b = 1.57316(3), c = 1.59810(3) nm) and its mixtures with four excipients was investigated with DSC and TG. Melting point is 163.6 °C (∆f H = 33 kJ mol−1). Smaller values reported recently were measured for not pure samples. The melt of betulin dipropionate remains glassy under ambient conditions and does not crystallize during the second heating. In mixture with excipients (arabinogalactan, polyethylene glycol, polyvinylpyrrolidone, and fumed silica), the betulin dipropionate loses its crystal structure after mechanical activation.
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The work was supported by Russian Foundation for Basic Research and the RAS program “Fundamental Sciences for Medicine.”
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10973_2013_3578_MOESM1_ESM.tif
Thermogravimetric results for the activated mixtures of betulin dipropionate with PEG (red) and AG (green). Solid lines are for TG and doted lines are for DTG (TIFF 121 kb)
10973_2013_3578_MOESM2_ESM.tif
Thermogravimetric results for the activated mixtures of betulin dipropionate with SiO2 (black) and PVP (blue). Solid lines are for TG and doted lines are for DTG (TIFF 121 kb)
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Drebushchak, V.A., Mikhailenko, M.A., Shakhtshneider, T.P. et al. Thermal properties of betulin dipropionate and its mixtures with polymers. J Therm Anal Calorim 115, 2521–2525 (2014). https://doi.org/10.1007/s10973-013-3578-1
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DOI: https://doi.org/10.1007/s10973-013-3578-1