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Thermal study of new biologic active complexes with mixed ligands

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Abstract

Five new coordinative compounds that contain mixed ligands (4,4′-bipyridine and methacrylate anion) were synthesized and characterized (elemental analysis, IR and UV–Vis spectroscopy, and thermal studies). The complexes are of the type [M(4,4′-bipy)(C4H5O2)2]·nH2O ((1) M:Mn, n = 0; (2) Co, n = 0.5; (3) M:Ni, n = 1.5; (4) M:Cu, n = 0.5; (5) M:Zn, n = 0.5; 4,4′-bipy: 4,4′-bipyridine; C4H5O2: methacrylate anion). All the tested complexes exhibited very low MIC values against Escherichia coli strains and one compound against Staphylococcus aureus. Besides the specific antimicrobial spectrum, these compounds also inhibited the microbial ability to colonize the inert surfaces, acting as potential anti-adherence and biofilm-controlling agents. The thermal behavior provided confirmation of the complexes' compositions as well as the number and the nature of water molecules and the intervals of thermal stability.

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Authors and Affiliations

  1. Department of Soil Sciences, University of Agronomical Sciences and Veterinary Medicine, 59 Mărăşti Str., Sector 1, 011464, Bucharest, Romania

    Gina Vasile

  2. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., Sector 5, 050663, Bucharest, Romania

    Rodica Olar, Dana Marinescu, Angela Kriza & Mihaela Badea

  3. Faculty of Biology, Department of Microbiology, University of Bucharest, 1-3 Portocalelor Str., Sector 6, 060101, Bucharest, Romania

    Luminita Marutescu, Mariana Carmen Chifiriuc & Veronica Lazar

Authors
  1. Gina Vasile
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  2. Rodica Olar
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  3. Dana Marinescu
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  4. Angela Kriza
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  5. Luminita Marutescu
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  6. Mariana Carmen Chifiriuc
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  7. Veronica Lazar
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  8. Mihaela Badea
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Correspondence to Mihaela Badea.

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Vasile, G., Olar, R., Marinescu, D. et al. Thermal study of new biologic active complexes with mixed ligands. J Therm Anal Calorim 111, 1783–1790 (2013). https://doi.org/10.1007/s10973-012-2317-3

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  • DOI: https://doi.org/10.1007/s10973-012-2317-3

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