Article

Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 3, pp 1015-1021

Stability studies of capecitabine

  • M. ŁaszczAffiliated withDepartment of R and D Analytical Chemistry, Pharmaceutical Research Institute Email author 
  • , K. TrzcińskaAffiliated withDepartment of R and D Analytical Chemistry, Pharmaceutical Research Institute
  • , K. FilipAffiliated withDepartment of R and D Analytical Chemistry, Pharmaceutical Research Institute
  • , A. SzyprowskaAffiliated withDepartment of R and D Analytical Chemistry, Pharmaceutical Research Institute
  • , M. MuchaAffiliated withDepartment of R and D Analytical Chemistry, Pharmaceutical Research Institute
  • , P. KrzeczyńskiAffiliated withDepartment of Chemistry, Pharmaceutical Research Institute

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Abstract

Differential scanning calorimetry and thermogravimetry techniques were successfully used for stability studies of capecitabine. Decreasing values of melting temperature, heat of fusion, and peak purity calculated from the Van’t Hoff equation indicated the gradual decomposition of capecitabine stored at 40 °C in 75% of relative humidity. The increase in mass loss connected with the water sorption was observed simultaneously. High performance liquid chromatography proved the results of thermoanalytical studies. Infrared spectroscopy (IR) appeared to have the lower sensitivity for the decomposition products detection.

Keywords

Thermal analysis IR HPLC Capecitabine