Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 3, pp 1015–1021

Stability studies of capecitabine

  • M. Łaszcz
  • K. Trzcińska
  • K. Filip
  • A. Szyprowska
  • M. Mucha
  • P. Krzeczyński
Article

DOI: 10.1007/s10973-011-1351-x

Cite this article as:
Łaszcz, M., Trzcińska, K., Filip, K. et al. J Therm Anal Calorim (2011) 105: 1015. doi:10.1007/s10973-011-1351-x

Abstract

Differential scanning calorimetry and thermogravimetry techniques were successfully used for stability studies of capecitabine. Decreasing values of melting temperature, heat of fusion, and peak purity calculated from the Van’t Hoff equation indicated the gradual decomposition of capecitabine stored at 40 °C in 75% of relative humidity. The increase in mass loss connected with the water sorption was observed simultaneously. High performance liquid chromatography proved the results of thermoanalytical studies. Infrared spectroscopy (IR) appeared to have the lower sensitivity for the decomposition products detection.

Keywords

Thermal analysisIRHPLCCapecitabine

Supplementary material

10973_2011_1351_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 33 kb)

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  • M. Łaszcz
    • 1
  • K. Trzcińska
    • 1
  • K. Filip
    • 1
  • A. Szyprowska
    • 1
  • M. Mucha
    • 1
  • P. Krzeczyński
    • 2
  1. 1.Department of R and D Analytical ChemistryPharmaceutical Research InstituteWarsawPoland
  2. 2.Department of ChemistryPharmaceutical Research InstituteWarsawPoland