Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 3, pp 1015–1021

Stability studies of capecitabine

Authors

    • Department of R and D Analytical ChemistryPharmaceutical Research Institute
  • K. Trzcińska
    • Department of R and D Analytical ChemistryPharmaceutical Research Institute
  • K. Filip
    • Department of R and D Analytical ChemistryPharmaceutical Research Institute
  • A. Szyprowska
    • Department of R and D Analytical ChemistryPharmaceutical Research Institute
  • M. Mucha
    • Department of R and D Analytical ChemistryPharmaceutical Research Institute
  • P. Krzeczyński
    • Department of ChemistryPharmaceutical Research Institute
Article

DOI: 10.1007/s10973-011-1351-x

Cite this article as:
Łaszcz, M., Trzcińska, K., Filip, K. et al. J Therm Anal Calorim (2011) 105: 1015. doi:10.1007/s10973-011-1351-x

Abstract

Differential scanning calorimetry and thermogravimetry techniques were successfully used for stability studies of capecitabine. Decreasing values of melting temperature, heat of fusion, and peak purity calculated from the Van’t Hoff equation indicated the gradual decomposition of capecitabine stored at 40 °C in 75% of relative humidity. The increase in mass loss connected with the water sorption was observed simultaneously. High performance liquid chromatography proved the results of thermoanalytical studies. Infrared spectroscopy (IR) appeared to have the lower sensitivity for the decomposition products detection.

Keywords

Thermal analysis IR HPLC Capecitabine

Supplementary material

10973_2011_1351_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 33 kb)

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011