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Application of thermal analysis and pyrolysis coupled to GC/MS in the qualification of simvastatin pharmaceutical raw material

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Abstract

The simvastatin (SV) is nowadays produced semi-synthetically from lovastatin. It’s one of the statins most commonly used to treat several forms of hypercholesterolemia. This study aimed to apply the thermal characterization of the SV raw material using thermoanalytical techniques and its degradation products by Pyrolysis coupled to Gas chromatography/Mass spectrometry (Pyr-GC/MS). It was studied three samples of SV (SVA, SVB, and SVC). The results showed thermal behavior differences of the samples during the melting process transition and the activation energies (E a) of the thermal decomposition, which were correlated to the thermal stability of them. The first decomposition step of Pyr-GC/MS showed two new compounds of m/z 284 and 207, in proportions dependents according to the pyrolysis temperature.

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References

  1. British Pharmacopoeia. London: United Kingdon, 2009.

  2. Metcalfe CD, Miao XS. Determination of cholesterol-lowering statin drugs in aqueous samples using liquid chromatography-electrospray ionisation tandem mass spectrometry. J Chromatogr A. 2003;998:133–41.

    Article  Google Scholar 

  3. Cheng SZD, Li CY, Calhoun BH, Zhu L, Zhou WW. Thermal analysis: the next two decades. Thermochim Acta. 2000;355:59–68.

    Article  CAS  Google Scholar 

  4. Moura EA, Correia LP, Pinto MF, Procópio JVV, de Souza FS, Macêdo RO. Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/EM. J Therm Anal Calorim. 2010;100:289–93.

    Article  CAS  Google Scholar 

  5. da Silva RMF, de Medeiros FPM, Nascimento TG, Macêdo RO, Neto PJR. Thermal characterization of indinavir sulfate using TG, DSC, and DSC-photovisual. J Therm Anal Calorim. 2009;95(3):1–4.

    Google Scholar 

  6. Shulga O, Dunn J. A simultaneous TG–DTA study of the thermal decomposition of 2-hydroxybenzoic acid, 2-carboxyphenyl ester (salsalate). Thermochim Acta. 2004;410:15–21.

    Article  CAS  Google Scholar 

  7. Chawla G, Gupta P, Thilagavathi R, Chakraborti AK, Bansal AK. Characterization of solid-state forms of celecoxib. Euro J Pharm Sci. 2003;20:305–17.

    Article  CAS  Google Scholar 

  8. Medeiros AFD, Santos AFO, de Souza FS, Júnior IDB, Valdilanio J, Procópio JVV, de Santana DP, Macêdo RO. Thermal studies of pre-formulates of metronidazole obtained by spray drying technique. J Therm Anal Calorim. 2007;89(3):775–81.

    Article  CAS  Google Scholar 

  9. Medeiros AFD, Santos AFO, de Souza FS, Procópio JVV, Pinto MF, Macêdo RO. Thermal stability of paracetamol and its pre-formulates obtained by spray drying. J Therm Anal Calorim. 2007;88(2):377–82.

    Article  CAS  Google Scholar 

  10. Macêdo RO, Nascimento TG. Quality control of thiabendazole pre-formulation and tablets by TG and DSC coupled to the photovisual system. Thermochim Acta. 2002;393:85–92.

    Article  Google Scholar 

  11. Gomes APB, Correia LP, Simoes MOS, Macêdo RO. Development of thermogravimetric method to quantitative determination of mebendazole. J Therm Anal Calorim. 2007;87(3):919–25.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors thank financing Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) for the technical and financial support.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, PB, 58059-970, Brazil

    José Valdilânio Virgulino Procópio, Valmir Gomes de Souza, Fábio Santos de Souza & Rui Oliveira Macêdo

  2. Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

    José Valdilânio Virgulino Procópio, Rodrigo Albuquerque da Costa, Lidiane Pinto Correia, Fábio Santos de Souza & Rui Oliveira Macêdo

Authors
  1. José Valdilânio Virgulino Procópio
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  2. Valmir Gomes de Souza
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  3. Rodrigo Albuquerque da Costa
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  4. Lidiane Pinto Correia
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  5. Fábio Santos de Souza
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  6. Rui Oliveira Macêdo
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Correspondence to José Valdilânio Virgulino Procópio.

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Procópio, J.V.V., de Souza, V.G., da Costa, R.A. et al. Application of thermal analysis and pyrolysis coupled to GC/MS in the qualification of simvastatin pharmaceutical raw material. J Therm Anal Calorim 106, 665–670 (2011). https://doi.org/10.1007/s10973-010-1274-y

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  • DOI: https://doi.org/10.1007/s10973-010-1274-y

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