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Carvone functionalized iron oxide nanostructures thin films prepared by MAPLE for improved resistance to microbial colonization

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Abstract

In this study, we aimed to improve and extend the microbiological applications of magnetic nanocarriers, by the successful fabrication of a new nanostructured surface based on 7 nm average diameter magnetite and carvone (Fe3O4@CAR) nanoparticles and to evaluate the biological activity of this material deposed as a thin film by advanced laser techniques (MAPLE). The results demonstrate that the thin surfaces containing the fabricated bio-active nanosystem have a great antimicrobial activity, inhibiting the colonization and biofilm formation of both Gram positive and Gram negative tested species. Furthermore, the in vitro results demonstrate that this material is not cytotoxic, allowing the normal growth and development of human endothelial cells. Our results demonstrate that the fabricated magnetic bioactive nanostructured surfaces have a great potential to be used for the development of novel applications on the medical field, particularly in the control of infectious diseases.

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Acknowledgments

The work has been funded by the Sectoral Operational Programme Human Resources Development 2007–2013 of the Ministry of European Funds through the Financial Agreement POSDRU/159/1.5/S/132397 (ExcelDOC).

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Authors and Affiliations

  1. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061, Bucharest, Romania

    Alina Maria Holban, Ecaterina Andronescu, Valentina Grumezescu, Alexandra Elena Oprea & Alexandru Mihai Grumezescu

  2. Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalilor Lane, Sector 5, 77206, Bucharest, Romania

    Alina Maria Holban & Veronica Lazar

  3. Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, Magurele, Romania

    Valentina Grumezescu & Gabriel Socol

  4. Department of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, “Nicolae Simionescu”, 8, B.P. Hasdeu, 050568, Bucharest, Romania

    Florin Iordache

  5. Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Research Institute of the University of Bucharest, 1-3 Portocalilor Lane, Sector 5, 77206, Bucharest, Romania

    Mariana Carmen Chifiriuc

Authors
  1. Alina Maria Holban
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  2. Ecaterina Andronescu
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  3. Valentina Grumezescu
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  4. Alexandra Elena Oprea
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  5. Alexandru Mihai Grumezescu
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  6. Gabriel Socol
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  7. Mariana Carmen Chifiriuc
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  8. Veronica Lazar
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  9. Florin Iordache
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Correspondence to Alexandru Mihai Grumezescu.

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Holban, A.M., Andronescu, E., Grumezescu, V. et al. Carvone functionalized iron oxide nanostructures thin films prepared by MAPLE for improved resistance to microbial colonization. J Sol-Gel Sci Technol 73, 605–611 (2015). https://doi.org/10.1007/s10971-014-3552-9

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  • DOI: https://doi.org/10.1007/s10971-014-3552-9

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