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A novel theranostic nanobioconjugate: 125/131I labeled phenylalanine conjugated boron nitride nanotubes

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Abstract

Here we report the synthesis of boron nitride nanotubes (BNNTs) via a chemical vapor deposition method, as potential agents for boron neutron capture therapy. BNNTs were functionalized with PAMAM[G-2] dendrimer and then, conjugated with l-Phe using EDC/NHS. After that, BNNTs were radiolabeled with 125/131I, which are commonly used for both therapy and diagnosis in clinical and pre-clinical studies. BNNTs were radiolabeled with a maximum yield with 125/131I in compared with 4-borono-l-phenyalanine which is currently used as a commercial drug. Radiolabeling parameters were optimized with thin layer radiochromatography and high performance liquid radiochromatography. BNNTs are promising nanobioconjugates as new theranostic agents.

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Acknowledgements

The authors thank to the Ege University Scientific Research Fund for the financial support through the project number 2015 NBE 002. Associate Professor Arzu Turkler Ege and Associate Professor Mehmet Ayvacikli from Celal Bayar University are acknowledged for their valuable helps during the synthesis step of BNNTs. Dr Hasan Demiroglu from Celal Bayar University is acknowledged for his helps during FTIR measurements.

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Authors and Affiliations

  1. Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey

    Ozge Kozgus Guldu & Perihan Unak

  2. Department of Biochemistry, Faculty of Sciences, Ege University, 35100, Bornova, Izmir, Turkey

    Suna Timur

Authors
  1. Ozge Kozgus Guldu
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  2. Perihan Unak
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  3. Suna Timur
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Correspondence to Perihan Unak.

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Guldu, O.K., Unak, P. & Timur, S. A novel theranostic nanobioconjugate: 125/131I labeled phenylalanine conjugated boron nitride nanotubes. J Radioanal Nucl Chem 311, 1751–1762 (2017). https://doi.org/10.1007/s10967-016-5127-4

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