Abstract
A comparative evaluation of two methods for the production of 172Tm in nuclear reactors is carried out. They are respectively based on two chains of double neutron capture reactions, 170Er(n,γ)171Er(n,γ)172Er(β−)172Tm and 170Er(n,γ)171Er(β−)171Tm(n,γ)172Tm, and a chain of triple neutron capture: 169Tm(n,γ)170Tm(n,γ)71Tm(n,γ)172Tm. Theoretical considerations with respect to both ways of production are formulated and the mathematical equation are solved. Experiments of irradiation of Er2O3 and Tm2O3 were performed. Advantages and drawbacks of both methods are discussed.
Similar content being viewed by others
References
Melcer E (2007) Evolución temporal de las actividades inducidas por doble captura neutrónica en isótopos de erbio y tulio. Graduation paper. Facultad Regional Buenos Aires, Universidad Tecnológica Nacional, República Argentina
Alí Santoro MC, Fornaciari Iljadica MC, Cohen IM (2013) The production of 172Tm by triple neutron capture in nuclear reactors. J Radioanal Nucl Chem 298:1973–1976
Neves M, Kling A, Oliveira A (2005) Radionuclides used for therapy and suggestion for new candidates. J Radioanal Nucl Chem 266:377–384
Das T, Chakraborty S, Sarma HD, Tandon P, Banerjee S, Venkatesha M, Maroor RAP (2009) 170Tm-EDTMP: a potential cost-effective alternative to 89SrCl2 for bone pain palliation. Nucl Med Biol 36:561–568
Kusum V, Das T, Sarma HD, Banerjee S, Pillai MRA (2013) Radiolabeling, stability studies, and pharmacokinetic evaluation of thulium-170-labeled acyclic and cyclic polyaminopolyphosphonic acids. Cancer Biother Radiopharm 28:737–745
Shirvani-Arani S, Bahrami-Samani A, Meftahi M, Jalilian AR, Ghannadi-Maragheh M (2013) Production, quality control and biodistribution studies of thulium-170-labeled ethylenediamine (tetramethylene phosphonic acid). Radiochim Acta 101:37–44
Magill J, Pfennig G, Dreher R, Sóti Z (2012) Karlsruher Nuklidkarte, 8. Auflage Laboratoire National Henri Becquerel, Recommended Data http://www.nucleide.org/DDEP_WG/DDEPdata.htm. Accessed September 2014
National Nuclear Data Center, Brookhaven National Laboratory, Nudat 2.5 http://www.nndc.bnl.gov/nudat2. Accessed September 2014
Wieser ME, Holden N, Coplen TB, Böhlke JK, Berglund M, Brand WA, De Bièvre P, Gröning M, Loss RD, Meija J, Hirata T, Prohaska Th, Schoenberg R, O’Connor G, Walczyk Th, Yoneda Sh, Xiang-Kun Zh (2013) Atomic weights of the elements 2011 (IUPAC Technical Report). Pure Appl Chem 85(5):1047–1078
Berglund M, Wieser ME (2011) Isotopic compositions of the elements 2009 (IUPAC Technical Report). Pure Appl Chem 83(2):397–410
Sahiralamkhan M, Chakravarty R, Chakraborty S, Kamaleshwaran KK, Shinto A, Dash A (2015) Irradiation parameters play a crucial role in the (n, γ) production of 170Tm suitable for clinical use in bone pain palliation. J Radioanal Nucl Chem. doi:10.1007/s10967-015-4323-y
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cohen, I.M., Hayes, A. & Melcer, E. Comparative evaluation of two methods for 172Tm production in nuclear reactors. J Radioanal Nucl Chem 308, 947–953 (2016). https://doi.org/10.1007/s10967-015-4595-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10967-015-4595-2