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Radiosynthesis of 123I-labeled hesperetin for biodistribution study of orally administered hesperetin

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Abstract

The purpose of this study is to synthesize 123I-labeled hesperetin and to investigate its in vivo behavior. The optimized labeling condition provided two isomers of 123I-labeled hesperetin with high radiochemical yields and radiochemical purities. Both 123I-labeled products were orally administered to normal ICR mice, and the initial result showed that most of 123I activity was detected in the stomach and the intestines. A part of 123I-labeled hesperetin was absorbed from the small intestine to bloodstream and then it was distributed in normal organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative organ distribution of orally administered hesperetin.

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Acknowledgments

This work was supported by the National Research Foundation of Korea grant funded by the Korea government (Grant Nos. 2012M2B2B1055245 and 2012M2A2A6011335) and Korea Atomic Energy Research Institute.

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Authors and Affiliations

  1. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk, 580-185, Republic of Korea

    Jongho Jeon, So-Young Ma, Dae Seong Choi, Beom-Su Jang, Jung Ae Kang, You Ree Nam, Seonhye Yoon & Sang Hyun Park

  2. Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and Technology, Daejeon, 305-350, Republic of Korea

    Sang Hyun Park

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  1. Jongho Jeon
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Correspondence to Sang Hyun Park.

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Jeon, J., Ma, SY., Choi, D.S. et al. Radiosynthesis of 123I-labeled hesperetin for biodistribution study of orally administered hesperetin. J Radioanal Nucl Chem 306, 437–443 (2015). https://doi.org/10.1007/s10967-015-4093-6

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  • DOI: https://doi.org/10.1007/s10967-015-4093-6

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