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Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation

Part II. The conventional column chromatographic separation combined with HPLC for high purity

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Abstract

HPLC technique combined with the simple conventional column solid phase extraction (SPE) chromatography using di-(2-ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) was developed for the separation of no-carrier added (n.c.a) 177Lu from the bulk quantity of ytterbium target. This combination strategy was based on combining the advantages of the better resolution of HPLC separation of n.c.a 177Lu from the few milligram level Yb target with the high capacity of the OASISHDEHP column for the separation of 177Lu from the bulk Yb target. The production batches of several hundred mCi activity of n.c.a 177Lu radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron flux (Φ=5·1013 n·cm−2·s−1) were successfully performed using this combined separation technique. With the target irradiation in a reactor of higher thermal neutron flux or with the parallel run of several separation units, several Ci-s of n.c.a 177Lu can be profitably produced on a commercial production basis.

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Authors and Affiliations

  1. Radiopharmaceutical Research Institute, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights, Menai, P.M.B 1, NSW, 2234, Australia

    Le Van So, N. Morcos, M. Zaw, P. Pellegrini, I. Greguric & A. Nevissi

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  1. Le Van So
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  2. N. Morcos
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  3. M. Zaw
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  4. P. Pellegrini
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  5. I. Greguric
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  6. A. Nevissi
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Correspondence to Le Van So.

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Van So, L., Morcos, N., Zaw, M. et al. Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation. J Radioanal Nucl Chem 277, 675–683 (2008). https://doi.org/10.1007/s10967-007-7130-2

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  • DOI: https://doi.org/10.1007/s10967-007-7130-2

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