Skip to main content
SpringerLink
Log in

Preparation of macroporous chitosan patch using co-solvent as a transdermal drug-delivery system

  • Published:
Journal of Porous Materials Aims and scope Submit manuscript

Abstract

As a simple method, bio-patches of band type have been widely used in various medical areas for more than 70 years. Despite their numerous advantages, drawbacks such as a lack of adhesive strength and low efficiency of transdermal drug delivery have limited their application. To improve the convenience of use, a 3D porous chitosan patch was prepared simply by phase separation of a solvent (acidic water)/co-solvent [dimethyl carbonate (DMC)]. As a tackifìer of low cytotoxicity, allyl 2-cyanoacrylate bio-glue was prepolymerized and coated onto the porous chitosan patch. Various properties were examined, such as mechanical strength, efficiency of drug-delivery, morphology, cytotoxicity and degradability. We ascertained that the optimal ratio of co-solvent for achieving a highly porous chitosan patch was DMC at a ratio of 5 %. The resultant drug release by the optimal highly porous chitosan patch was approximately twofold faster than that of the untreated control. The porous patch showed improved efficiency of cell adhesion after culturing in cells for 4 h. After 72 h, the cultured cells showed increased cell proliferation on the porous patches. These results strongly suggest that the chitosan-based porous patches covered with modified cyanoacrylate can be widely used as good adhesive patches in various incidents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. L.Y. Lee, S.C. Wu, S.S. Fu, S.Y. Zeng, W.S. Leong, L.P. Tan, Eur. Polym. J. 45, 3249 (2009)

    Article  CAS  Google Scholar 

  2. H. Cao, N. Kuboyama, Bone 46, 386 (2010)

    Article  CAS  Google Scholar 

  3. J. Penoff, Plast. Reconstr. Surg. 103, 730 (1999)

    Article  CAS  Google Scholar 

  4. H.W. Sung, D.M. Huang, W.H. Chang, L.L. Huang, C.C. Tsai, I.L. Liang, J. Biomater. Sci. Polym. Ed. 10, 751 (1999)

    Article  CAS  Google Scholar 

  5. F.J. Papatheofanis, J. Biomed. Mater. Res. 23, 661 (1989)

    Article  CAS  Google Scholar 

  6. F. Chen, Y. Su, X. Mo, C. He, H. Wang, Y. Ikada, J. Biomater. Sci. Polym. Ed. 20, 2117 (2009)

    Article  CAS  Google Scholar 

  7. S.E. Fischer, X. Liu, H.O. Mao, J.L. Harden, Biomaterials 28, 3325 (2007)

    Article  CAS  Google Scholar 

  8. H. Shen, X. Hu, J. Bei, S. Wang, Biomaterials 29, 2388 (2008)

    Article  CAS  Google Scholar 

  9. M. Schakenraad, P.J. Dijkstra, Clin. Mater. 7, 253 (1991)

    Article  CAS  Google Scholar 

  10. C. Choong, J.P. Griffiths, M.G. Moloney, J. Triffitt, D. Swallow, React. Funct. Polym. 69, 77 (2009)

    Article  CAS  Google Scholar 

  11. H. Wang, J. Ji, W. Zhang, Y. Zhang, J. Jiang, Z. Wu, S. Pu, P.K. Chu, Acta Biomater. 5, 279 (2009)

    Article  CAS  Google Scholar 

  12. C.E. Evans, G.C. Lees, I.A. Trail, J. Hand, Surg. Br. 24(6), 658 (1999)

    CAS  Google Scholar 

  13. T. Mosmann, Rapid J. Immunol. Methods 65(1–2), 55 (1983)

    Article  CAS  Google Scholar 

  14. H. Iwata, S. Matsuda, K. Mitsuhashi, E. Itoh, Y. Ikada, Biomaterials 19, 1869 (1998)

    Article  CAS  Google Scholar 

  15. K. Ono, Y. Saito, H. Yura, K. Ishikawa, A. Kurita, T. Akaike, M. Ishihara, J. Biomed. Mater. Res. 49(2), 289 (2000)

    Article  CAS  Google Scholar 

  16. F.S. El-Askary, M.S. Nassif, A.S. Fawzy, J. Adhes. Dent. 10(6), 471 (2008)

    CAS  Google Scholar 

  17. I.Z. Schroeder, P. Frank, U.F. Schaefer, C.M. Lehr, Eur. J. Pharm. Biopharm. 65, 111 (2007)

    Article  Google Scholar 

  18. K. Premphet, P. Hpranont, J. Appl. Polym. Sci. 76, 1929 (2000)

    Article  CAS  Google Scholar 

  19. R. Guo, X. Du, R. Zhang, L. Deng, A. Dong, J. Zhang, Eur. J. Pharm. Biopharm. 79(3), 574 (2011)

    Article  CAS  Google Scholar 

  20. J.I. Lim, J.H. Kim, H.K. Park, Mater. Lett. 81, 251 (2012)

    Article  CAS  Google Scholar 

  21. J.I. Lim, H.K. Park, Korea Patent 10-2011-0115354 (2011)

  22. E. Khor, L.Y. Lim, Biomaterials 24, 2339 (2003)

    Article  CAS  Google Scholar 

  23. J.H. Waite, X.X. Qin, J. Coyne, Matrix Biol. 17, 93 (1998)

    Article  CAS  Google Scholar 

  24. K. Inoue, Y. Takeuchi, D. Miki, S. Odo, J. Biol. Chem. 270(12), 6698 (1995)

    Article  CAS  Google Scholar 

  25. G. Kratz, C. Arnander, J. Swedenborg, M. Back, C. Falk, I. Gouda, O. Larm, J. Plast. Reconstr. Surg. Hand Surg. 31, 119 (1997)

    Article  CAS  Google Scholar 

  26. S. Miyazaki, K. Ishii, T. Nadai, Chem. Pharm. Bull. (Tokyo) 29(10), 3067 (1981)

    Article  CAS  Google Scholar 

  27. K. Aiedeh, E. Gianasi, I. Orienti, V. Zecchi, J. Microencapsul. 14(5), 567 (1997)

    Article  CAS  Google Scholar 

  28. S. Miyazaki, H. Yamaguchi, M. Takada, W.M. Hou, Y. Takeichi, H. Yasubuchi, Acta Pharm. Nord. 2(6), 401 (1990)

    CAS  Google Scholar 

  29. B. Yang, X.Y. Li, S. Shi, X.Y. Kong, G. Guo, M. Huang, F. Luo, Y.Q. Wei, X. Zhao, Z.Y. Qian, Carbohydr. Polym. 80(3), 860 (2010)

    Article  CAS  Google Scholar 

  30. S.V. Madihally, H.W. Matthew, Biomaterials 20(12), 1133 (1999)

    Article  CAS  Google Scholar 

  31. B. Porstmann, K. Jung, H. Schmechta, U. Evers, M. Pergande, T. Porstmann, Clin. Biochem. 22, 349 (1989)

    Article  CAS  Google Scholar 

  32. T. Masuda, Y. Ueno, N. Kitabatake, J. Agric. Food Chem. 49, 4937 (2001)

    Article  CAS  Google Scholar 

  33. M.M.C.G. Silva, L.A. Cyster, J.J.A. Barry, X.B. Yang, R.O.C. Oreffo, D.M. Grant, C.A. Scotchford, S.M. Howdle, K.M. Shakesheff, F.R.A.J. Rose, Biomaterials 27, 5909 (2006)

    Article  CAS  Google Scholar 

  34. C. Ji, J. Shi, Mater. Sci. Eng. C 33, 3780 (2013)

    Article  CAS  Google Scholar 

  35. A.C. Jones, C.H. Arns, D.W. Hutmacher, B.K. Milthorpe, A.P. Sheppard, M.A. Knackstedt, Biomaterials 30, 1440 (2009)

    Article  CAS  Google Scholar 

  36. J.I. Lim, Y.K. Lee, J.S. Shin, K.J. Lim, J. Biomater. Sci. 22, 1319 (2011)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University, Jukjeon-dong, Yongin-si, Gyeonggi-do, Republic of Korea

    Jin Ik Lim & Woo-Kul Lee

Authors
  1. Jin Ik Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Woo-Kul Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Woo-Kul Lee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lim, J.I., Lee, WK. Preparation of macroporous chitosan patch using co-solvent as a transdermal drug-delivery system. J Porous Mater 21, 783–788 (2014). https://doi.org/10.1007/s10934-014-9825-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10934-014-9825-4

Keywords

Search

Navigation