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Synthesis of magnetic mesoporous silica composites via a modified Stöber approach

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Abstract

In this work, magnetic Fe3O4@mesoporous silica composites were synthesized by a microemulsion (oil-in-water/ethanol) approach which was applied with a modified Stöber reaction. Cetyl trimethyl ammonium bromide was employed as the surfactant, nano-Fe3O4 particles were dispersed in microemulsion. Tetraethyl orthosilicate (TEOS) formed oil drops, and ammonia solution facilitated the hydrolysis polymerization of TEOS. The diameters of the magnetic Fe3O4@mesoporous silica composites can be tuned within the range 120–380 nm by varying the ratio of ethanol/water and the amount of nano-Fe3O4 particles. Brunauer–Emmett–Teller surface areas of magnetic Fe3O4@mesoporous silica composites were determined to be within the range 490–759 m2/g and their pore sizes were around 2.3 nm as it was determined by Barrett–Joyner–Halenda method. Furthermore, the encapsulation of poorly water-soluble drugs within magnetic Fe3O4@mesoporous silica composites was investigated using protoporphyrin IX. Magnetic Fe3O4@mesoporous silica composites showed a drug loading within 22–68 mg/g, which can be an excellent drug delivery platform for photodynamic therapy.

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Acknowledgments

The work was supported by the National Natural Science Foundation of China (No. 20803031) and National Found for Fostering Talents of basic Science (No. J1103202).

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Authors and Affiliations

  1. College of Physics, Jilin University, No.2699 Qianjin Street, Changchun, 130012, China

    Fei Wang, Ziheng Li, Dan Liŭ, Guoqiang Wang & Dan Liú

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  1. Fei Wang
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  2. Ziheng Li
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  3. Dan Liŭ
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  4. Guoqiang Wang
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Correspondence to Ziheng Li.

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Wang, F., Li, Z., Liŭ, D. et al. Synthesis of magnetic mesoporous silica composites via a modified Stöber approach. J Porous Mater 21, 513–519 (2014). https://doi.org/10.1007/s10934-014-9798-3

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