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Anti-neoplastic Applications of Heparin Coated Magnetic Nanoparticles Against Human Ovarian Cancer

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Abstract

This study determines the effect of bare and heparin (HP)-based magnetic iron oxide (Fe3O4) nanoparticles (MNPs) on the human ovarian cancer cells of CP70 type. Cisplatin (CP) was used as the anticancer drug, entrapped in MNPs. The nanoparticles containing the anticancer drug, CP, were prepared by a solvent evaporation and emulsification cross-linking method. The physicochemical properties of the nanoparticles were characterized by various techniques, and uniform particles of bare and HP coated MNPs, with average particle sizes of 25 and 45 ± 15 nm, having high encapsulation efficiencies, were obtained. Additionally, a sustained release of CP from the MNPs was successful in vitro. Cytotoxicity tests showed that the MNP–HP–CP had higher cell toxicity than the individual HP; and confocal microscopic analysis confirmed excellent cellular uptake efficiency of CP70 cells for MNP–HP–CP. These results indicate that HP based MNPs have potential uses as anticancer drug carriers and have also proved to have enhanced anti-neoplastic effects.

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References

  1. S. Nie, Y. Xing, G.J. Kim, J.W. Simons, Annu. Rev. Biomed. Eng. 9, 257 (2007)

    Article  CAS  Google Scholar 

  2. C.C.M. You, O.R. Gider, B. Ghosh, S.P. Kim, I. Erdogan, B. Krovi, S.A. Bunz, U.H.F. Rotello, Nat. Nanotechnol. 2, 318 (2007)

    Article  CAS  Google Scholar 

  3. M. Ferrari, Nat. Rev. Cancer 5, 161 (2005)

    Article  CAS  Google Scholar 

  4. S. Kommareddy, M. Amiji, Bioconjug. Chem. 16, 1423 (2005)

    Article  CAS  Google Scholar 

  5. D.B. Pike, S. Cai, K.R. Pomraning, M.A. Firpo, R.J. Fisher, X.Z. Shu, Biomaterials 27, 5242 (2006)

    Article  CAS  Google Scholar 

  6. R.J. Linhardt, Chem. Biol. 11, 420 (2007)

    Article  Google Scholar 

  7. M.K. Yu, D.Y. Lee, Y.S. Kim, K. Park, S.A. Park, D.H. Son, Pharm. Res. 24, 705 (2007)

    Article  CAS  Google Scholar 

  8. T.K. Jain, M.A. Morales, S.K. Sahoo, D.L. Leslie-Pelecky, V. Labhasetwar, Mol. Pharmacol. 2, 194 (2005)

    Article  CAS  Google Scholar 

  9. M. Vandana, S. Sahoo, Nanomedicine 4, 773 (2009)

    Article  CAS  Google Scholar 

  10. S.K. Sahoo, V. Labhasetwar, Drug Discov. Today 8, 1112 (2003)

    Article  CAS  Google Scholar 

  11. X. Liu, M.D. Kaminski, Y. Guan, H. Chen, H. Liu, A.J. Rosengart, J. Magn. Magn. Mater. 306, 248 (2006)

    Article  CAS  Google Scholar 

  12. E. Strable, J.W.M. Bulte, B. Moskowitz, K. Vivekanandan, M. Allen, T. Douglas, Chem. Mater. 13, 2201 (2001)

    Article  CAS  Google Scholar 

  13. Q.L. Guo, Q.D. You, Z.Q. Wu, S.T. Yuan, L. Zhao, Acta Pharmacol. Sin. 25, 769 (2004)

    CAS  Google Scholar 

  14. Q.L. Guo, S.S. Lin, Q.D. You, Life Sci. 78, 1238 (2006)

    Article  CAS  Google Scholar 

  15. Q.L. Guo, S.S. Lin, Q.D. You, Life Sci. 79, 125 (2007)

    Article  Google Scholar 

  16. T.T. Wang, J. Wei, X.P. Qian, Y.T. Ding, L.X. Yu, B.R. Liu, Cancer Lett. 262, 214 (2008)

    Article  CAS  Google Scholar 

  17. K.K. Gilles, I. Joseph, J. Nanobiotechnol. 4, 8 (2006)

    Article  Google Scholar 

  18. B.L. Lin, X.D. Shen, S. Cui, Biomed. Mater. 2, 132 (2007)

    Article  CAS  Google Scholar 

  19. J.C. Reed, Curr. Opin. Oncol. 7, 541 (1995)

    Article  CAS  Google Scholar 

  20. B.A. Chen, Q. Sun, X.M. Wang, Int. J. Nanomedicine 3, 277 (2008)

    CAS  Google Scholar 

  21. B.A. Chen, J. Cheng, Y.N. Wu, Int. J. Nanomedicine 4, 73 (2009)

    Article  CAS  Google Scholar 

  22. B.A. Chen, J. Cheng, M.F. Shen, Int. J. Nanomedicine 4, 65 (2009)

    Article  CAS  Google Scholar 

  23. K. Yacobi, A. Wojtowicz, A. Tsafriri, A. Gross, Endocrinology 145, 1943 (2004)

    Article  CAS  Google Scholar 

  24. N. Takai, T. Ueda, M. Nishida, K. Nasu, K. Miyakawa, Curr. Cancer Drug Targets 4, 511 (2004)

    Article  CAS  Google Scholar 

  25. D.C. Altieri, Oncogene 22, 8581 (2003)

    Article  CAS  Google Scholar 

  26. X. Ling, R.J. Bernacki, M.G. Brattain, F.Z. Li, J. Biol. Chem. 279, 15196 (2004)

    Article  CAS  Google Scholar 

  27. S.P. Tu, J.T. Cui, P. Liston, Gastroenterology 128, 361 (2005)

    Article  CAS  Google Scholar 

  28. D.C. Altieri, Nat. Rev. Cancer 3, 46 (2003)

    Article  CAS  Google Scholar 

  29. J.M. Adams, S. Cory, Science 281, 1322 (1998)

    Article  CAS  Google Scholar 

  30. H.J.M.M. Mertens, M.J. Heineman, J.L.H. Evers, Gynecol. Obstet. Invest. 53, 224 (2002)

    Article  CAS  Google Scholar 

  31. C.M.J.L. Tilli, A.J.W. Stavast-Koey, F.C.S. Ramaekers, H.A.M. Neumann, J. Cutan. Pathol. 29, 79 (2002)

    Article  Google Scholar 

  32. F. Pettersson, A.G. Dalgleish, R.P. Bissonnette, K.W. Colston, Br. J. Cancer 87, 555 (2002)

    Article  CAS  Google Scholar 

  33. V. Kirkin, S. Joos, M. Zornig, Biochim. Biophys. Acta 1644, 229 (2004)

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Payame Noor University, Esfahān, Iran

    Mohammad Fazilati

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  1. Mohammad Fazilati
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Correspondence to Mohammad Fazilati.

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Fazilati, M. Anti-neoplastic Applications of Heparin Coated Magnetic Nanoparticles Against Human Ovarian Cancer. J Inorg Organomet Polym 24, 551–559 (2014). https://doi.org/10.1007/s10904-013-0005-9

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  • DOI: https://doi.org/10.1007/s10904-013-0005-9

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