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Prevalence and Morbidity of Primary Immunodeficiency Diseases, United States 2001–2007

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Abstract

Purpose

Few studies have estimated population prevalence and morbidity of primary immunodeficiency diseases (PIDD). We used administrative healthcare databases to estimate the prevalence of PIDD diagnoses in the United States from 2001 to 2007.

Methods

MarketScan databases compile claims from commercial health insurance plans and Medicaid, recording individual diagnoses for outpatient encounters and hospital stays. We used a cross sectional survey to estimate prevalence of PIDD using related ICD-9 codes (279.0, 279.1, 279.2, 279.8, 279.9, 288.1 and 288.2). Persons with secondary immunodeficiency diagnoses were excluded from analysis.

Results

Between 2001 and 2007, prevalence of any PIDD diagnosis increased from 38.9 to 50.5 per 100,000 among privately insured and from 29.1 to 41.1 per 100,000 among publicly insured persons. B cell defects predominated. Prevalence was more than twice as high among Whites as among Blacks or Hispanics.

Conclusion

In this large database, we found a higher prevalence of diagnosed PIDD than has been reported previously from registries. Increased awareness may have contributed to the increasing prevalence.

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Acknowledgments

This research was supported in part by an appointment (RWP) to the Research Participation Program at the CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. Thanks to the Jeffrey Modell Foundation for promoting awareness of Primary Immune Deficiencies.

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Dr., Atlanta, GA, 30322, USA

    Lisa Kobrynski

  2. Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA

    Rachel Waltenburg Powell & Scott Bowen

Authors
  1. Lisa Kobrynski
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  2. Rachel Waltenburg Powell
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  3. Scott Bowen
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Correspondence to Lisa Kobrynski.

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The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

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Kobrynski, L., Powell, R.W. & Bowen, S. Prevalence and Morbidity of Primary Immunodeficiency Diseases, United States 2001–2007. J Clin Immunol 34, 954–961 (2014). https://doi.org/10.1007/s10875-014-0102-8

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  • DOI: https://doi.org/10.1007/s10875-014-0102-8

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