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Th22, but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus

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Abstract

Purpose

T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythematosus (SLE) remains unclear. The present study intends to investigate their roles in SLE.

Methods

Clinical data were collected in 65 SLE patients and 30 healthy controls. The patients were divided into active and inactive groups. CD4+IFN-γ−IL-17−IL-22+Tcells (Th22 cells),CD4+ IFN-γ−IL-22−IL-17+T cells (Th17 cells),and CD4+ IFN-γ+ (Th1 cells) were assayed by flow cytometry. Serum interleukin-22 (IL-22) and IL-17 levels were measured by enzyme-linked immunosorbent assay.

Results

The main observation focused on increased Th22 cells in patients with sole lupus skin disease and decreased Th22 cells in patients with sole lupus nephritis. Likewise, concentrations of serum IL-22 were increased in patients with sole lupus skin disease, and decreased in patients with sole lupus nephritis. Additionally, there was a positive correlation between the percentage of Th22 cells and IL-22 production. The percentage of Th17 cells or concentration of serum IL-17 correlated positively with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).

Conclusion

Th22 seems to be a more significant index to predict the tissue involvement of SLE than Th17, although Th17 may play a role in the activity of SLE.

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Acknowledgments

This study was partially supported by grant from Science Foundation of Science and Technology Department of Zhejiang Province (No.2007C3305) and (No.2009C3012-4).

Disclosures

The authors have no financial conflict of interest.

The authors have nothing to disclose.

Author information

Authors and Affiliations

  1. Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China

    Xu-yan Yang & Li-juan Wang

  2. Department of Allergy and Clinical Immunology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, People’s Republic of China

    Hui-ying Wang

  3. Department of Hematology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Rd, Hangzhou, Zhejiang, 310009, People’s Republic of China

    Xiao-ying Zhao

  4. Department of Immunology Laboratory, Institute of cancer research, Zhejiang University, Hangzhou, 310009, People’s Republic of China

    Qing-hua Lv

  5. Department of Immunology, Institute of Basic Medical Sciences,College of Medicine, Zhejiang University, Hangzhou, 310058, People’s Republic of China

    Qing-qing Wang

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  1. Xu-yan Yang
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Correspondence to Xiao-ying Zhao.

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Yang, Xy., Wang, Hy., Zhao, Xy. et al. Th22, but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus. J Clin Immunol 33, 767–774 (2013). https://doi.org/10.1007/s10875-013-9878-1

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