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Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice

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Abstract

During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that although the basic roadmap of blood development is generally conserved across mammals, evolutionary pressures have generated many differences between the species that have important biological and translational implications. To enhance the utility of the mouse as a model organism, it is more important than ever that research data are presented with regard to how they might be influenced by the species of origin as well as the developmental source of the hematopoietic tissue.

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Acknowledgments

CP is a St. Baldrick’s Foundation Scholar and is the recipient of a St. Baldrick’s scholar award, and a CHLA K12 Child Health Research Career Development Award. This work was also supported by National Institutes of Health (P01 HL073104 and 1P01AI072686) and the California Institute of Regenerative Medicine (RM1-01707) to G.M.C.

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Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Chintan Parekh

  2. Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Chintan Parekh

  3. Department of Pathology & Laboratory Medicine, Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA

    Gay M. Crooks

  4. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA

    Gay M. Crooks

  5. Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA

    Gay M. Crooks

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  1. Chintan Parekh
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  2. Gay M. Crooks
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Correspondence to Gay M. Crooks.

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Parekh, C., Crooks, G.M. Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice. J Clin Immunol 33, 711–715 (2013). https://doi.org/10.1007/s10875-012-9844-3

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  • DOI: https://doi.org/10.1007/s10875-012-9844-3

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