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Molecular Characterization of Human Plasmacytoid Dendritic Cells

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Abstract

Introduction

Plasmacytoid dendritic cells (pDCs) represent a unique and important immune cell population capable of producing large quantifies of type I interferon (IFN) in response to viruses as well as nucleic acid-containing complexes from the host. These rare and mysterious cells have been revealed by in-depth molecular characterization. Several innate sensors and signaling molecules enriched in pDCs allow their specialized innate immune functions. In addition, human pDCs use a group of surface receptors that, through activation of a B-cell receptor (BCR)-like signaling pathway, modulate type I IFN responses. It is clear now that pDC development is influenced by distinctive transcription factors that specify a unique lineage. CD4+CD56+ hematodermic neoplasm of human pDC origin has been revealed in explicit molecular terms.

Conclusion

A detailed molecular description of pDCs helps us better define, understand, and track human pDCs in relation to their functions and physiological involvement.

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Acknowledgments

This review was supported by a grant from the National Institutes of Health and funds from M. D. Anderson Cancer Center.

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  1. Department of Immunology, Unit 901, 7455 Fannin, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA

    Wei Cao

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  1. Wei Cao
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Correspondence to Wei Cao.

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Cao, W. Molecular Characterization of Human Plasmacytoid Dendritic Cells. J Clin Immunol 29, 257–264 (2009). https://doi.org/10.1007/s10875-009-9284-x

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  • DOI: https://doi.org/10.1007/s10875-009-9284-x

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