Article

Journal of Clinical Immunology

, Volume 27, Issue 5, pp 461-466

Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus

  • Hye-Young ChunAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Jae-Wook ChungAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Hyoun-Ah KimAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Jeong-Moon YunAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Ja-Young JeonAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Young-Min YeAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Seung-Hyun KimAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Hae-Sim ParkAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine
  • , Chang-Hee SuhAffiliated withDepartment of Allergy and Rheumatology, Ajou University School of Medicine Email author 

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Abstract

There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.

Keywords

Systemic lupus erythematosus biomarker cytokines