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The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

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An Erratum to this article was published on 22 September 2007

Natural killer (NK) cell alloreactions against recipient cells in the setting of bone marrow transplantation have been associated with decreased rates of graft-versus-host disease (GVHD) and improved survival in transplant recipients with myeloid leukemia. These alloreactions are predicted by the absence of recipient HLA class I ligands for donor inhibitory killer Ig-like receptors (KIR). We hypothesized that donor NK cell alloreactions against recipient cells may affect the development of T and B-cell functions and incidence of GVHD in infants with severe combined immunodeficiency (SCID). Of the 156 patients with SCID who had received related bone marrow transplants without pretransplant chemotherapy or posttransplant GVHD prophylaxis, 137 patient–donor pairs were evaluated for the absence of recipient HLA class I ligands for donor inhibitory KIR. Analysis showed that the absence of a KIR ligand had no effect on the incidence or severity of GVHD (R 2 = 0.95, p = 0.84), development of T-cell function (R 2 = 1.05, p = 0.69), production of IgA (p = 0.46) or IgM (p = 0.33), or on 5-year survival (R 2 = 1.21, p = 0.10). Further, in patients possessing native NK cells, the absence of KIR ligands in donors for recipient-inhibitory KIR did not alter transplantation outcomes. This study suggests that inhibitory KIR/HLA interactions do not play a significant role in bone marrow transplantation for SCID.

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Acknowledgments

This research was supported by NIH Grant 5R01-AI/HD042951-07 and the Howard Hughes Medical Institute Research Fellows Program. The authors would like to thank Ms. Adella Clark, Ms. Myriah Cooney, Ms. Donna Oliver, Ms. Roberta Parrott, and Ms. Elisa Sajaroff, for their excellent technical assistance, and Ms. Lora DeRubeis for her administrative work. We would also like to thank Dr. Eric Long, Dr. Sumi Rajagopalan, and Dr. Andreas Velardi for kindly sharing their protocols and advice. We are also grateful to Dr. Peter Parham for his generosity in providing cell lines, and Steven Grambow for his expertise in our statistical analyses.

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Authors and Affiliations

  1. Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, USA

    M. D. KELLER & R. H. BUCKLEY

  2. Clinical Transplantation Immunology Laboratory, Duke University Medical Center, Durham, North Carolina, USA

    D.-F. CHEN, N. LIU & N. L. REINSMOEN

  3. Duke School of Medicine, Duke University Medical Center, Durham, North Carolina, USA

    S. A. CONDRON

  4. Duke University Medical Center, P.O. Box 2898, Durham, North Carolina, USA

    R. H. BUCKLEY

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  1. M. D. KELLER
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Correspondence to R. H. BUCKLEY.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10875-007-9116-9

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KELLER, M.D., CHEN, DF., CONDRON, S.A. et al. The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID). J Clin Immunol 27, 109–116 (2007). https://doi.org/10.1007/s10875-006-9058-7

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  • DOI: https://doi.org/10.1007/s10875-006-9058-7

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