Article

Journal of Clinical Immunology

, Volume 25, Issue 4, pp 329-337

Fetal Cord Blood: Aspects of Heightened Immune Responses

  • B. SchaubAffiliated withUniversity Children’s HospitalUniversity Children’s Hospital Email author 
  • , K. G. TantisiraAffiliated withChanning Laboratory, Brigham and Women’s Hospital
  • , F. K. GibbonsAffiliated withPulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School
  • , H. HeAffiliated withPulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School
  • , A. A. LitonjuaAffiliated withChanning Laboratory, Brigham and Women’s Hospital
  • , M. W. GillmanAffiliated withDepartment of Ambulatory Care and Prevention, Harvard Pilgrim Health Care
  • , S. WeissAffiliated withChanning Laboratory, Brigham and Women’s Hospital
  • , D. L. PerkinsAffiliated withImmunogenetics and Transplantation, Brigham and Women’s Hospital
  • , D. R. GoldAffiliated withChanning Laboratory, Brigham and Women’s Hospital
    • , P. W. FinnAffiliated withPulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School

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Abstract

Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-γ secretion. We determined whether LP to one allergen is related to heightened lymphocyte function to other allergens/mitogen. CBMC from 135 neonates were stimulated with house dust mite (Derf1), cockroach, ovalbumin, or mitogen. LP to one allergen was associated with significantly increased LP to other allergens/mitogen. Increased Derf1-LP was associated with increased Derf1-induced IL-13 secretion (r = 0.21, p = 0.01). After adjusting for neonatal gender, race, and maternal smoking, Derf1-LP remained associated with Derf1-IL-13 (OR 3.08, 95% CI 1.56–6.10). Increased mitogen-induced proliferation was associated with increased mitogen-induced IL-13 secretion (r = 0.37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation.

Key Words

Allergens cord blood immunology lymphocytes neonatal