Journal of Clinical Immunology

, Volume 25, Issue 4, pp 329–337

Fetal Cord Blood: Aspects of Heightened Immune Responses

Authors

    • University Children’s Hospital
    • University Children’s Hospital
  • K. G. Tantisira
    • Channing LaboratoryBrigham and Women’s Hospital
  • F. K. Gibbons
    • Pulmonary and Critical Care DivisionBrigham and Women’s Hospital, Harvard Medical School
  • H. He
    • Pulmonary and Critical Care DivisionBrigham and Women’s Hospital, Harvard Medical School
  • A. A. Litonjua
    • Channing LaboratoryBrigham and Women’s Hospital
  • M. W. Gillman
    • Department of Ambulatory Care and PreventionHarvard Pilgrim Health Care
  • S. Weiss
    • Channing LaboratoryBrigham and Women’s Hospital
  • D. L. Perkins
    • Immunogenetics and TransplantationBrigham and Women’s Hospital
  • D. R. Gold
    • Channing LaboratoryBrigham and Women’s Hospital
  • P. W. Finn
    • Pulmonary and Critical Care DivisionBrigham and Women’s Hospital, Harvard Medical School
Article

DOI: 10.1007/s10875-005-4180-5

Cite this article as:
Schaub, B., Tantisira, K.G., Gibbons, F.K. et al. J Clin Immunol (2005) 25: 329. doi:10.1007/s10875-005-4180-5

Abstract

Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-γ secretion. We determined whether LP to one allergen is related to heightened lymphocyte function to other allergens/mitogen. CBMC from 135 neonates were stimulated with house dust mite (Derf1), cockroach, ovalbumin, or mitogen. LP to one allergen was associated with significantly increased LP to other allergens/mitogen. Increased Derf1-LP was associated with increased Derf1-induced IL-13 secretion (r = 0.21, p = 0.01). After adjusting for neonatal gender, race, and maternal smoking, Derf1-LP remained associated with Derf1-IL-13 (OR 3.08, 95% CI 1.56–6.10). Increased mitogen-induced proliferation was associated with increased mitogen-induced IL-13 secretion (r = 0.37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation.

Key Words

Allergenscord bloodimmunologylymphocytesneonatal
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Copyright information

© Springer Science + Business Media, Inc. 2005