Abstract
Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria.
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This work was supported by the Serbian Ministry of Science (Grant No. 175037).
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Ostojic, S.M. Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria. J Bioenerg Biomembr 47, 369–372 (2015). https://doi.org/10.1007/s10863-015-9619-7
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DOI: https://doi.org/10.1007/s10863-015-9619-7