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Mitochondria in relation to cancer metastasis

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Abstract

Mitochondria, also known as “Power House of cell,” are crucial organelles, regulating energy metabolism. Recently, an involvement of mitochondria in cancer occurrence and metastasis has been proposed. The roles of mitochondria in cancer progression/metastasis include alteration of glycolysis, regulation of ROS and suppression of intrinsic apoptosis. This mini-review explains the specific mitochondrial characteristics during cancer metastasis with past and recent findings. It may contribute to understanding mitochondria-related mechanisms of cancer metastasis.

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, 561-180, Korea

    Bidur Bhandary, Anu Marahatta & Han-Jung Chae

  2. Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan, 570-749, Korea

    Hyung-Ryong Kim

Authors
  1. Bidur Bhandary
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  2. Anu Marahatta
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  3. Hyung-Ryong Kim
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  4. Han-Jung Chae
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Correspondence to Hyung-Ryong Kim or Han-Jung Chae.

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Bhandary, B., Marahatta, A., Kim, HR. et al. Mitochondria in relation to cancer metastasis. J Bioenerg Biomembr 44, 623–627 (2012). https://doi.org/10.1007/s10863-012-9464-x

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  • DOI: https://doi.org/10.1007/s10863-012-9464-x

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