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Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications

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Abstract

Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano- and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.

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Acknowledgments

This study was supported by the Ministry of Economy and Competitiveness (MINECO) of the Spanish Government (Project: MAT2012-30706).

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Authors and Affiliations

  1. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Laboratori de Microscòpia Electrònica, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal Pavelló E (Etseib)-Planta 0, 647-08028, Barcelona, Spain

    Alejandra Rodríguez-Contreras, Francisco Javier Gil & José María Manero

  2. Departament d’Òptica i Optometria, Universitat Politècnica de Catalunya-Barcelona TECH, Sant Nebridi 22, 08222, Terrassa Barcelona, Spain

    María Soledad Marqués-Calvo

  3. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Biomaterials, Biomechanics and Tissue Engineering Group, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal, 647-08028, Barcelona, Spain

    Francisco Javier Gil & José María Manero

  4. CIBER-BBN, Centro de Investigación Biomédica en Red, Madrid, Spain

    Francisco Javier Gil & José María Manero

Authors
  1. Alejandra Rodríguez-Contreras
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  2. María Soledad Marqués-Calvo
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Correspondence to Alejandra Rodríguez-Contreras.

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Rodríguez-Contreras, A., Marqués-Calvo, M.S., Gil, F.J. et al. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. J Mater Sci: Mater Med 27, 124 (2016). https://doi.org/10.1007/s10856-016-5723-4

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  • DOI: https://doi.org/10.1007/s10856-016-5723-4

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