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A glass polyalkenoate cement carrier for bone morphogenetic proteins

  • Biomaterials Synthesis and Characterization
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Abstract

This work considers a glass polyalkenoate cement (GPC)-based carrier for the effective delivery of bone morphogenetic proteins (BMPs) at an implantation site. A 0.12 CaO–0.04 SrO–0.36 ZnO–0.48 SiO2 based glass and poly(acrylic acid) (PAA, Mw 213,000) were employed for the fabrication of the GPC. The media used for the water source in the GPC reaction was altered to produce a series of GPCs. The GPC liquid media was either 100 % distilled water with additions of albumin at 0, 2, 5 and 8 wt% of the glass content, 100 % formulation buffer (IFB), and 100 % BMP (150 µg rhBMP-2/ml IFB). Rheological properties, compressive strength, ion release profiles and BMP release were evaluated. Working times (Tw) of the formulated GPCs significantly increased with the addition of 2 % albumin and remained constant with further increases in albumin content or IFB solutions. Setting time (Ts) experienced an increase with 2 and 5 % albumin content, but a decrease with 8 % albumin. Changing the liquid source to IFB containing 5 % albumin had no significant effect on Ts compared to the 8 % albumin-containing BT101. Replacing the albumin with IFB/BMP-2 did not significantly affect Tw. However, Ts increased for the BT101_BMP-2 containing GPCs, compared to all other samples. The compressive strength evaluated 1 day post cement mixing was not affected significantly by the incorporation of BMPs, but the ion release did increase from the cements, particularly for Zn and Sr. The GPCs released BMP after the first day, which decreased in content during the following 6 days. This study has proven that BMPs can be immobilized into GPCs and may result in novel materials for clinical applications.

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Acknowledgments

The authors thank the Natural Sciences and Engineering Research Council of Canada (NSERC) Engage Program (Grant #449,981-13) for facilitating this research.

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Authors and Affiliations

  1. Department of Mechanical & Industrial Engineering, Faculty of Engineering and Architectural Science, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada

    Adel M. F. Alhalawani, Omar Rodriguez, Declan J. Curran, Russell Co, Sean Kieran, Saad Arshad & Mark R. Towler

  2. Inamori School of Engineering, Alfred University, Alfred, New York, NY, USA

    Timothy J. Keenan & Anthony W. Wren

  3. Faculty of Dentistry, Dental Research Institute, University of Toronto, Toronto, ON, Canada

    Gazelle Crasto & Sean A. F. Peel

  4. Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, Malaysia

    Mark R. Towler

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  1. Adel M. F. Alhalawani
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Correspondence to Declan J. Curran.

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Alhalawani, A.M.F., Rodriguez, O., Curran, D.J. et al. A glass polyalkenoate cement carrier for bone morphogenetic proteins. J Mater Sci: Mater Med 26, 151 (2015). https://doi.org/10.1007/s10856-015-5494-3

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