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Fabrication and characterization of porous Ti–7.5Mo alloy scaffolds for biomedical applications

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Abstract

Porous titanium and titanium alloys are promising scaffolds for bone tissue engineering, since they have the potential to provide new bone tissue ingrowth abilities and low elastic modulus to match that of natural bone. In the present study, porous Ti–7.5Mo alloy scaffolds with various porosities from 30 to 75 % were successfully prepared through a space-holder sintering method. The yield strength and elastic modulus of a Ti–7.5Mo scaffold with a porosity of 50 % are 127 MPa and 4.2 GPa, respectively, being relatively comparable to the reported mechanical properties of natural bone. In addition, the porous Ti–7.5Mo alloy exhibited improved apatite-forming abilities after pretreatment (with NaOH or NaOH + water) and subsequent immersion in simulated body fluid (SBF) at 37 °C. After soaking in an SBF solution for 21 days, a dense apatite layer covered the inner and outer surfaces of the pretreated porous Ti–7.5Mo substrates, thereby providing favorable bioactive conditions for bone bonding and growth. The preliminary cell culturing result revealed that the porous Ti–7.5Mo alloy supported cell attachment.

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Acknowledgments

The authors express appreciation to Dr. Cheryl Rutledge, Associate Professor of English, Da-Yeh University, for her editorial assistance. The authors acknowledge the partial financial support of Taichung Veterans General Hospital and Da-Yeh University (TCVGH-DYU1008302).

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Authors and Affiliations

  1. Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC

    Hsueh-Chuan Hsu, Shih-Kuang Hsu & Shih-Ching Wu

  2. Institute of Biomedical Engineering and Materials Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC

    Hsueh-Chuan Hsu, Shih-Kuang Hsu & Shih-Ching Wu

  3. Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC

    Hsi-Kai Tsou

  4. Department of Mechanical and Automation Engineering, Da-Yeh University, Changhua, Taiwan, ROC

    Tsung-Hsuan Lai

  5. Department of Materials Science and Engineering, Da-Yeh University, 168 University Road, 51591, Dacun, Changhua, Taiwan, ROC

    Wen-Fu Ho

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  1. Hsueh-Chuan Hsu
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Correspondence to Wen-Fu Ho.

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Hsu, HC., Hsu, SK., Tsou, HK. et al. Fabrication and characterization of porous Ti–7.5Mo alloy scaffolds for biomedical applications. J Mater Sci: Mater Med 24, 645–657 (2013). https://doi.org/10.1007/s10856-012-4843-8

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