Article

Journal of Materials Science: Materials in Medicine

, Volume 23, Issue 10, pp 2583-2592

Plasma polypyrrole implants recover motor function in rats after spinal cord transection

  • Guillermo J. CruzAffiliated withDepartamento de Física, Instituto Nacional de Investigaciones Nucleares
  • , Rodrigo Mondragón-LozanoAffiliated withDepartamento de Física, Universidad Autónoma Metropolitana Iztapalapa
  • , Araceli Diaz-RuizAffiliated withDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía
  • , Joaquín ManjarrezAffiliated withLaboratorio de Fisiología de la Formación Reticular, Instituto Nacional de Neurología y Neurocirugía
  • , Roberto OlayoAffiliated withDepartamento de Física, Universidad Autónoma Metropolitana Iztapalapa
  • , Hermelinda Salgado-CeballosAffiliated withUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
  • , Maria-Guadalupe OlayoAffiliated withDepartamento de Física, Instituto Nacional de Investigaciones Nucleares
  • , Juan MoralesAffiliated withDepartamento de Física, Universidad Autónoma Metropolitana Iztapalapa
  • , Laura Alvarez-MejíaAffiliated withDepartamento de Física, Universidad Autónoma Metropolitana Iztapalapa
    • , Axayacatl MoralesAffiliated withDepartamento de Física, Universidad Autónoma Metropolitana Iztapalapa
    • , Marisela Méndez-ArmentaAffiliated withDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía
    • , Noel PlascenciaAffiliated withCentro Médico Nacional 20 de Noviembre, ISSSTE
    • , Maria del Carmen FernandezAffiliated withDepartamento de Electrofisiología, Instituto Nacional de Neurología y Neurocirugía
    • , Camilo RíosAffiliated withDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

We studied the use of three biocompatible materials obtained by plasma polymerization of pyrrole (PPy), pyrrole doped with iodine (PPy/I) and a copolymer formed with pyrrole and polyethylene glycol (PPy/PEG), implanted, separately, after a complete spinal cord transection in rats. Motor function assessed with the BBB scale and somatosensory evoked potentials (SEPs) in the implanted rats were studied. Results showed that the highest motor recovery was obtained in rats with PPy/I implants. They also showed a significant reduction in the latency of SEPs. Histological analyses showed no signs of implant rejection; on the contrary, implants based on PPy improved the SEPs conduction and motor function after lesion.