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Injectability evaluation of tricalcium phosphate bone cement

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Abstract

Calcium phosphate cements are biomaterials made from a mixture of calcium phosphate powder in aqueous solutions that forms a paste that reacts at the body temperature and hardens as a result of precipitation reactions. These cements are commonly used in dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The challenge consists in formulating an injectable paste by additives incorporation. In this work, three different additives (carboxymethylcellulose, agar polymer and sodium alginate) were incorporated to tricalcium phosphate, in concentrations of 0.4, 0.8, 1.6, 3.2 and 6.4 wt.%. Injectability was evaluated through a new method developed for this purpose. Results showed that it was possible to obtain injectable compositions of α-tricalcium phosphate cement. It was verified that the injectability depends on the rheological behavior of the pastes and injection time. In this study, pastes with viscosity suitable for good homogenization and injection were obtained.

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Acknowledgements

The authors thank the additives suppliers for material donation and the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES) for financial support.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Federal University of Rio Grande do Sul, Avenida Osvaldo Aranha, 99, 705c, Centro, Porto Alegre, RS, 90620-000, Brazil

    Hugo Leonardo Rocha Alves, Luis A. dos Santos & Carlos P. Bergmann

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  1. Hugo Leonardo Rocha Alves
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  2. Luis A. dos Santos
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  3. Carlos P. Bergmann
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Correspondence to Hugo Leonardo Rocha Alves.

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Alves, H.L.R., dos Santos, L.A. & Bergmann, C.P. Injectability evaluation of tricalcium phosphate bone cement. J Mater Sci: Mater Med 19, 2241–2246 (2008). https://doi.org/10.1007/s10856-007-3329-6

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  • DOI: https://doi.org/10.1007/s10856-007-3329-6

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